Vol. 45 (6): 1209-1215, November – December, 2019
Soheila Siroosbakht 1, Sadra Rezakhaniha 2, Bijan Rezakhaniha 3
1 Faculty of Medicine, Imam Reza Hospital, AJA University of Medical Sciences, Tehran, Iran; 2 Department of Nutrition, Science and Research Islamic Azad University, Tehran, Iran; 3 Department of Urology, Imam Reza Hospital, AJA University of Medical Sciences, Tehran, Iran
Purpose: To compare the effi cacy and safety of available selective serotonin reuptake inhibitors (SSRIs) in order to fi nd the most effective drug with the least number of side effects in treatment of premature ejaculation (PE).
Materials and Methods: This study was a randomized clinical trial. Four hundred and eighty patients with PE in the 4 groups referred to Imam Reza hospital Tehran, Iran from July 2018 to February 2019 were enrolled in the study. The patients received sertraline 50mg, fl uoxetine 20mg, paroxetine 20mg and citalopram 20mg, every 12 hours daily. The intravaginal ejaculatory latency time (IELT) before treatment, fourth and eighth weeks after treatment was recorded by the patient’s wife with a stopwatch.
Results: Mean IELT before, 4 and 8 weeks after treatment in four groups were: sertraline 69.4±54.3, 353.5±190.4, 376.3±143.5; fl uoxetine 75.5±64.3, 255.4±168.2, 314.8±190.4; paroxetine 71.5±69.1, 320.7±198.3, 379.9±154.3; citalopram 90.39±79.3, 279.9±192.1, 282.5±171.1 seconds, respectively. The ejaculation time signifi cantly increased in all groups (p <0.05), but there was no signifi cant difference between the groups (P=0.75). Also, there was no signifi cant difference in drugs side effects between groups (p >0.05). The most common side effects were drowsiness and dyspepsia, which were not severe enough to cause discontinuation of the drug.
Conclusions: All available SSRIs were effective and usually had no serious complications.
In patients who did not respond to any of these drugs, other SSRI drugs could be used as a salvage therapy.
Keywords: Citalopram; Fluoxetine; Premature Ejaculation