Prostate brachytherapy with iodine-125 seeds: analysis of a single institutional cohort

Vol. 45 (x): 2019 January 1.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2018.0142


Elton Trigo Teixeira Leite 1, 2, João Luis Fernandes da Silva 1, Eduardo Capelletti 1, Cecilia Maria Kalil Haddad 1, Gustavo Nader Marta 1, 2
1 Departamento de Radioterapia, Hospital Sirio-Libanês, São Paulo, SP, Brasil; 2 Serviço de Radioterapia – Departamento de Oncologia da Universidade de São Paulo, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, SP, Brasil


Objectives: Brachytherapy (BT) with iodine-125 seeds placement is a consolidated treatment for prostate cancer. The objective of this study was to assess the clinical outcomes in patients with prostate cancer who underwent low-dose-rate (LDR) –BT alone in a single Brazilian institution.
Materials and Methods: Patients treated with iodine-125 BT were retrospectively assessed after at least 5 years of follow-up.
Patients who received combination therapy (External beam radiation therapy-EBRT and BT) and salvage BT were not included.
Results: 406 men were included in the study (65.5% low-risk, 30% intermediate-risk, and 4.5% high-risk patients). After a median follow-up of 87.5 months, 61 (15.0%) patients developed biochemical recurrence. The actuarial biochemical failure-free survival (BFFS) at 5 and 10 years were 90.6% and 82.2%, respectively. A PSA nadir ≥ 1 ng / mL was associated with a higher risk of biochemical failure (HR = 5.81; 95% CI: 3.39 to 9.94; p ≤ 0.001). The actuarial metastasis-free survival (MFS) at 5 and 10 years were 98.3% and 94%, respectively. The actuarial overall survival (OS) at 5 and 10 years were 96.2% and 85.1%, respectively. Acute and late grade 2 and 3 gastrointestinal toxicities were observed in 5.6%, 0.5%, 4.6% and 0.5% of cases, respectively. For genitourinary the observed acute and late grade 2 and 3 toxicities rates were 57.3%, 3.6%, 28% and 3.1%, respectively. No grade 4 and 5 were observed.
Conclusions: BT was effective as a defi nitive treatment modality for prostate cancer, and its endpoints and toxicities were comparable to those of the main series in the literature.

Keywords: Brachytherapy; Iodine-125 [Supplementary Concept]; Prostate; Radiotherapy

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