Vol. 46 (x): 2020 March 3.[Ahead of print]
Zhenhua Liu 1, Haifeng Wang 2, Yuke Chen 1, Jie Jin 1, Wei Yu 1
1 Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China; 2 Department of Anesthesiology , Peking University First Hospital, Peking University, Beijing, China
Objectives: To explore the prognostic value of obesity (measured by BMI) on RCC in a systemic inflammation state.
Patients and Methods: Clinicopathological and hematological data of 540 surgically treated Chinese localized RCC patients between 2005 and 2010 were retrospectively collected. Found by receiver operating characteristic (ROC) curve for cancer-specific survival (CSS), the optimal cutoff values of neutrophil-lymphocyte ratio (NLR, an indicator of systemic inflammation state) and BMI were 2.12 and 23.32, respectively. Survival curves were drawn using Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of BMI in localized RCC patients with different NLR.
Results: Overall, 36 patients died with a median follow-up of 70 months. Median overall survival (OS) was 66 months and the 5-year OS rate was 92.7%. In the multivariate analysis of total patients, higher BMI was an independent protective factor for CSS in total patients (p=0.048). While in systemic inflammation subgroup (high NLR subgroup) patients, higher BMI (obesity) turned out to be an independent protective factor for both CSS (p=0.025) and RFS (p=0.048).
Conclusion: In localized RCC patients, obesity was an independent protective factor for CSS and RFS in a systemic inflammation state.
Keywords: Obesity; Carcinoma; Inflammation