Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis

Vol. 45 (x): 2019 August 8.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2019.0061


ORIGINAL ARTICLE


Jiaxuan Qin 1, Zonglong Cai 2, Jinchun Xing 1, Bo Duan 1, Peide Bai 1
1 Department of Urology Surgery, the First Affiliated Hospital of Xiamen University; Center of Diagnosis and Treatment of Urinary System Diseases, the First Affiliated Hospital of Xiamen University; the Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, the First Affiliated Hospital of Xiamen University. Xiamen, Fujian, China; 2 The First Clinical Medical School of Fujian Medical University. Xiamen, Fujian, China

ABSTRACT

Purpose: It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association.
Materials and Methods: A systematic search of studies on the association between CALCR gene polymorphisms and calcium stone urolithiasis susceptibility was con-ducted in databases.
Results: Odds ratios and 95% confi dence intervals were used to pool the effect size. Five articles were included in our meta-analysis.
Conclusions: CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insuffi cient data to fully confi rm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identifi ed in the current meta-analysis.

Keywords: Receptors, Calcitonin; Urolithiasis; Meta-Analysis [Publication Type]

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