Vol. 42 (3): 571-577, May – June, 2016
Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis
Ural Oguz 1, Zennure Takci 2, Isil Deniz Oguz 3, Berkan Resorlu 4, Ilknur Balta 5, Ali Unsal 6
1 Department of Urology, School of Medicine, University Giresun, Giresun, Turkey; 2 Department of Dermatology, School of Medicine, University Gaziosmanpasa, Tokat, Turkey; 3 Department of Dermatology, Prof. Dr. A. Ilhan Ozdemir State Hospital, Giresun, Turkey; 4 Department of Urology, School of Medicine, University Onsekiz Mart, Canakkale, Turkey; 5 Department of Dermatology, Kecioren Training and Research Hospital, Ankara, Turkey; 6 Department of Urology, School of Medicine, University Gazi, Ankara, Turkey
Purpose: to investigate whether patients with lichen planus (LP) are really prone to urolithiasis or not.
Patients and Methods: We performed a prospective analysis of 40 patients diagnosed with lichen planus (LP) (group I), and 40 volunteers did not have LP before (group II). Participants were all checked for urolithiasis by radiological investigations. Blood samples were analyzed for biochemistry parameters including calcium and uric acid. 24-h urine samples were analyzed to investigate oxalate, citrate calcium, uric acid, magnesium, sodium and creatinine.
Results: Men/women ratio and mean age were similar between group I and II (p>0.05). A presence or history of urolithiasis was detected in 8 (20%) and 2 (%5) patients in group I and II, respectively (p<0.05). Hypocitraturia was the most common anomaly with 35% (n:14) in group I. The rate of hypocitraturia in group II was 12.5% (n:5) and the difference was statistically significantly different (p=0.036). In group I, hyperuri¬cosuria and hyperoxaluria followed with rates of 27.5% (n:11) and 25% (n:10), respec¬tively. The rate of hyperuricosuria and hyperoxaluria were both 5% (n:2) in group II and the differences were significant (p<0.05). Hyperuricemia was another important finding in the patients with LP. It was detected in 13 (32.5%) patients in group I and in 1 (2.5%) participant in group II (p=0.001).
Conclusion: According to our results, metabolic disorders of urolithiasis were highly detected in the patients with LP. However, similar to the etiology of LP, the exact rea¬sons for these metabolic abnormalities in LP remain a mystery.
Keywords: Lichen Planus, Oral; Urolithiasis; Skin Diseases, Papulosquamous; Metabolic Diseases