ICSI with testicular sperm for couples with sperm DNA damage

Vol. 44 (4): 664-666, July – August, 2018

doi: 10.1590/S1677-5538.IBJU.2018.04.02


EDITORIAL

Armand Zini 1
1 Department of Surgery, St. Mary’s Hospital, McGill University, Montreal, Canada

The advent of intracytoplasmic sperm injection (ICSI) has revolutionized the management of male factor infertility (1). Shortly after the technique was introduced, studies demonstrated that ICSI could successfully treat couples with severe male factor infertility. Several investigators reported that neither sperm concentration, morphology, nor progressive motility had any impact on ICSI outcomes (2-4). However, the only sperm characteristic that portended a negative ICSI outcome was the injection of a totally immotile (and presumably dead) spermatozoon (4-6).

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