Original Article

Assessment of long term outcomes after buccal mucosal graft urethroplasty: the impact of chronic kidney disease

Vol. 45 (x): 2019 August 8.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2019.0176


ORIGINAL ARTICLE

Manoj Kumar 1, Ajay Aggarwal 1, Siddharth Pandey 1, Samarth Agarwal 1, Satya Narayan Sankhwar 1
1 Department of Urology, King George’s Medical University, Lucknow, INDIA

ABSTRACT

Objectives: To compare and assess various outcomes and success of buccal mucosal graft urethroplasty (BMGU) in patients with CKD versus patients having normal renal function.
Material and Methods: This was a retrospective, single centre study, during period 2013 to 2017. Patients were grouped into two groups. Group 1 had patients with estimated Glomerular Filtration Rate (eGFR)>60mL/min/1.73m2 while group 2 had patients with eGFR <60mL/min/1.73m2. eGFR was calculated according to the MDRD equation. The two groups were compared with regard to various outcomes like length, location of stricture, technique of graft placement, intra-operative blood loss (haemoglobin drop), duration of hospital stay, post-operative complications and recurrence.
Results: A total of 223 patients were included in study with group 1 had 130 patients and group 2 had 93 patients. Mean age of patients with CKD were higher (47.49 years versus 29.13 years). The mean follow-up period was comparable between both groups (23.29 months and 22.54 months respectively). Patients with CKD had more post-operative Clavien Grade 2 or higher complications (p=0.01) and a greater recurrence rates (p<0.001) than in non-CKD patients. On multivariate analysis, age and CKD status was signifi cant predictor of urethroplasty success (p=0.004) (OR= 14.98 (1.952-114.94, 95% CI).
Conclusions: CKD patients are more prone to post-operative complications in terms of wound infection, graft uptake and graft failure and higher recurrence rates following BMGU.

Keywords: Oral Mucosal Absorption; Renal...

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Comparison of the outcomes of laparoscopic pyeloplasty with and without concomitant pyelolithotomy

Vol. 45 (x): 2019 June 6.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2018.0781


ORIGINAL ARTICLE

Mustafa Kadihasanoglu 1, Ugur Yucetas 1, Emre Karabay 1, Erkan Sönmezay 1
1 Department of Urology, Istanbul Training & Research Hospital, Istanbul, Turkey

ABSTRACT

Objective: We aimed to evaluate the results of laparoscopic pyeloplasty with concomitant pyelolithotomy and compare results with a cohort of patients undergoing laparoscopic pyeloplasty without pyelolithotomy.
Materials and Methods: We retrospectively reviewed records of 43 patients undergoing transperitoneal laparoscopic Anderson-Hynes dismembered pyeloplasty between December 2012 and July 2018 at our department. Eighteen patients (42%) underwent laparoscopic pyeloplasty with concomitant pyelolithotomy. The results of patients with renal stones were compared with 25 matched patients undergoing laparoscopic pyeloplasty without concomitant renal stones. Demographic data, operative and stone parameters were compared between the groups.
Results: The groups were similar regarding to demographic characteristics. All operations were completed laparoscopically with no conversions to open surgery. In 3 cases without renal stones and 15 cases with renal stones, transposition of the ureter due to crossing vessels was performed. The mean stone size was 13±5.24 mm, and the median number of stones was 1 (1-18). The success of laparoscopic pyeloplasty with and without pyelolithotomy was 93.3% and 92.9%, respectively, as confirmed by negative diuretic renogram at postoperative 3rd months. Overall stone-free rate after laparoscopic pyelolithotomy was 93.3%. Mean operative time was 222.6765.71 minutes vs. 219.11±75.63 minutes for the pyeloplasty with concomitant pyelolithotomy vs. pyeloplasty, respectively (p=0.88).
Conclusions: Laparoscopic pyeloplasty with...

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Macroplastique for women with stress urinary incontinence secondary to intrinsic sphincter deficiency

Vol. 45 (x): 2019 August 8.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2019.0070


ORIGINAL ARTICLE

Timothy F. Carroll 1, Alana Christie 1, Melissa Foreman 1, Gaurav Khatri 1, Philippe E. Zimmern 1
1 University of Texas Southwestern Medical Center, TX, USA

ABSTRACT

Objective: To evaluate the subjective and objective outcomes of Macroplastique® (MPQ) in women with stress urinary incontinence (SUI) secondary to intrinsic sphincter de­ficiency (ISD).
Materials and Methods: Following Institutional Review Board (IRB) approval, charts of non-neurogenic women with SUI secondary to ISD who underwent MPQ injection and had 6 months minimum follow-up were reviewed from a prospectively maintained database. Patients were divided into 3 groups: Naïve (Group I), Prior Anti-Incontinence Surgery (Group II), and combined Prior Bulking Agent and Anti-Incontinence Surgery (Group III). Data collected included SUI self-report, Urogenital Distress Inventory (UDI- 6) Question 3, and VAS Quality of Life (QoL) Questionnaire scores at baseline and in follow-up. Three-dimensional ultrasound (3DUS) evaluated volume/configuration of MPQ. Success was defined after the last MPQ injection as a UDI-6 Question 3 score of 0 (dry) or 1, and no reoperation for SUI.
Results: From 2011-2017, 106 of 142 women met study criteria. At a median follow-up of 20 months (mean=26 months; range: 6-71), success rate was 41% for Group I, 40% for Group II, and 65% for Group III (p = 0.22). QoL scores were significantly improved over baseline in all groups. There was no significant difference in clinical outcome between the asymmetrical and symmetrical group on 3DUS. The completely dry rate was highest in Group III at 29%, compared to 4% for Group I and 15% for Group II (p = 0.05).
Conclusion: Macroplastique® improved subjective and objective outcome measures for SUI secondary to ISD as both a...

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Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis

Vol. 45 (x): 2019 August 8.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2019.0061


ORIGINAL ARTICLE


Jiaxuan Qin 1, Zonglong Cai 2, Jinchun Xing 1, Bo Duan 1, Peide Bai 1
1 Department of Urology Surgery, the First Affiliated Hospital of Xiamen University; Center of Diagnosis and Treatment of Urinary System Diseases, the First Affiliated Hospital of Xiamen University; the Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, the First Affiliated Hospital of Xiamen University. Xiamen, Fujian, China; 2 The First Clinical Medical School of Fujian Medical University. Xiamen, Fujian, China

ABSTRACT

Purpose: It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association.
Materials and Methods: A systematic search of studies on the association between CALCR gene polymorphisms and calcium stone urolithiasis susceptibility was con-ducted in databases.
Results: Odds ratios and 95% confi dence intervals were used to pool the effect size. Five articles were included in our meta-analysis.
Conclusions: CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insuffi cient data to fully confi rm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identifi ed in the current meta-analysis.

Keywords: Receptors, Calcitonin; Urolithiasis; Meta-Analysis [Publication Type]

[Full Text]


Prevalence of enuresis and its impact in quality of life of patients with sickle cell disease

Vol. 45 (x): 2019 August 8.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2019.0026


ORIGINAL ARTICLE

Alana de Medeiros Nelli 1, Flávia Cristina de Carvalho Mrad 2, Mateus de Andrade Alvaia 1, Heros Aureliano Antunes da Silva Maia 1, Carina Oliveira Silva Guimarães 3, Evanilda Souza de Santana Carvalho 3, Cristiano Mendes Gomes 3, José Murillo Bastos Netto 4,5,6, José de Bessa Junior 1,3
1 Departamento de Cirurgia Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brasil; 2 Departamento de Pediatria, Unidade de Nefrologia Pediátrica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.; 3 Programa de Pós-Graduação em Saúde Coeltiva, Universidade Federal de Juiz de Fora, Juiz de For a, MG, Brasil; 4 Departamento de Cirurgia, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora; 5 Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, MG, Brasil; 6 Hospital e Maternidade Terezinha de Jesus de Juiz de Fora, Juiz de Fora, MG, Brasil

 ABSTRACT

Introduction: Evidence indicates an increase in the prevalence of enuresis in individu-als with sickle cell disease. The present study aims to evaluate the prevalence and im- pact of enuresis on quality of life in individuals with sickle cell disease. Materials and Methods: This cross-sectional study evaluated individuals with sickle cell disease followed at a reference clinic, using a questionnaire designed to evaluate the age of complete toilet training, the presence of enuresis and lower urinary tract, and the impact on quality of life of these individuals. Results: Fifty children presenting SCD (52% females, mean age ten years) were in-cluded in the study. Of those, 34% (17/50) presented as HbSC, 56% with HbSS (28/50), 2% S_-thalassemia (1/5) and 8% the type of SCD was not determined. The prevalence of enuresis was 42% (21/50), affecting 75% of subjects at fi ve years...

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Improvement of fertility parameters with tribulus terrestris and Anacyclus Pyrethrum treatment in male rats

Vol. 45 (x): 2019 August 8.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2018.0843


ORIGINAL ARTICLE

Dariush Haghmorad 1,2, Mohammad Bagher Mahmoudi 3, Pardis Haghighi 4, Paria Alidadiani 4, Ensieh Shahvazian 4, Parsova Tavasolian 4, Mahmoud Hosseini 5, Mahmoud Mahmoudi 4
1 Department of Pathology and Laboratory Medicine, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran; 2 Department of Immunology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran; 3 Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; 4 Immunology Research Center, BuAli Research Institute, Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences; 5 Neuroscience Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences

ABSTRACT

Objective: Anacyclus Pyrethrum (AP) and Tribulus Terrestris (TT) have been reported as male infertility treatment in several studies; however, in Iranian traditional medicine these two plants are prescribed simultaneously. In this study, we aimed to determine the effects of AP and TT extracts both separately and simultaneously on the male Wi-star rat fertility parameters. Materials and Methods: 32 male Wistar rats were divided into 4 groups: Control, TT, AP, and AT treated groups. Treatment continued for 25 days and rats were weighed daily. Their testes were dissected for histological studies. Sperm analysis including sperm count, viability and motility were performed. Serum was obtained to evaluate testosterone, LH and FSH levels. Histological studies were conducted to study Leydig, and Sertoli cells, spermatogonia and spermatid cell numbers, and to measure seminif-erous diameter and epithelium thickness. Results: Sperm count increased in all the treatment groups. Sperm viability and mo-tility in AT and AP groups were...

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