Vol. 44 n. 3 May . Jun, 2018

Volume 44 | number 3 | May . June, 2018 – Urological myriad – The internationality and diversity of subjects have been remarkable characteristics of International
Braz J Urol, an open free access urological journal, as is this issue

Synchronous abdominal tumors: is combined laparoscopic surgery in a single approach a safe option?

Vol. 44 (3): 483-490, May – June, 2018 doi: 10.1590/S1677-5538.IBJU.2017.0429 ORIGINAL ARTICLE Marcelo Cartapatti 1, Roberto Dias Machado 1, Roberto Lodeiro Muller 1, Wesley J. Magnabosco 1, Alexandre César Santos 1, Brian Francis Chapin 2, Armando Melani 1, Antonio Talvane 1, Marcos Tobias-Machado 3, Eliney Ferreira Faria 1 1 Hospital de Câncer de Barretos, Barretos, SP, Brasil; 2 MD Anderson Cancer Center, Houston, TX, USA; 3 Faculdade de Medicina do ABC, Santo André, SP, Brasil   ABSTRACT   Background and Purpose: Recent advances in cancer treatment have resulted in bet­ter prognosis with impact on patient’s survival, allowing an increase in incidence of a second primary neoplasm. The development of minimally invasive surgery has provided similar outcomes in comparison to open surgery with potentially less mor­bidity. Consequently, this technique has been used as a safe option to simultaneously treat synchronous abdominal malignancies during a single operating room visit. The objective of this study is to describe the experience of two tertiary cancer hospitals in Brazil, in the minimally invasive treatment of synchronous abdominal neoplasms and to evaluate its feasibility and peri-operative results. Materials and Methods: We retrospectively reviewed the data from patients who were submitted to combined laparoscopic procedures performed in two tertiary hospitals in Brazil from May 2009 to February 2015. Results: A total of 12 patients (9 males and 3 females) with a mean age of 58.83 years (range: 33 to 76 years) underwent combined laparoscopic surgeries for the treatment of at least one urological disease. The total average duration of surgery was 339.8 minutes (range: 210 to 480 min). The average amount of intraoperative bleeding was 276.6mL (range: 70 to 550mL) and length of hospitalization was 5.08 days (range: 3 to 10 days). Two patients suffered minor complications regarding Clavien system during the immediate postoperative period. Conclusions: Combined laparoscopic surgery for the treatment of synchronous tumors is feasible, viable and safe. In our study, there was a low risk of postoperative morbidity.  Keywords: Laparoscopy; Neoplasms; Neoplasms, Multiple Primary [Full Text] Related Post High cancer detection rate using cognitive fusion – targeted tra... views 135 Is circumferential urethral mobilisation an overdo? A prospective outc... views 123 First – line, non – cryopreserved autologous stem cell tra... views 117 PCA3 rs544190G>A and prostate cancer risk in an eastern Chinese popula... views...

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Vaginal cuff recurrence after radical cystectomy: an under – studied site of bladder cancer relapse

Vol. 44 (3): 491-499, May – June, 2018 doi: 10.1590/S1677-5538.IBJU.2017.0376 ORIGINAL ARTICLE Fabio Zattoni 1, 2, Alessandro Morlacco 1, 2, Avinash Nehra 1, Igor Frank 1, Stephen A. Boorjian 1, Prabin Thapa 3, R. Jeffrey Karnes 1 1 Department of Urology, Mayo Clinic, Rochester, Minnesota, USA; 2 Clinica Urologica, Dipartimento di scienze Chirurgiche, Oncologiche e Gastroenterologiche, Azienda Ospedaliero – Universitaria di Padova, Padova, Italy; 3 Health Sciences Research, Mayo Clinic, Rochester, MN, USA ABSTRACT Introduction: Vaginal cuff recurrence of tumor following radical cystectomy is a rare site of disease recurrence, however it has never been specifically studied. The aim of the study is to evaluate incidence, risk factors, and long-term oncologic outcomes of vaginal cuff recurrence in a cohort of female patients treated with radical cystectomy for invasive urothelial carcinoma of the bladder. Materials and Methods: From 1985 to 2012, a prospectively maintained institutional bladder cancer registry was queried for vaginal cuff recurrence post radical cystectomy. Overall mortality and cancer-specific mortality were reported using the Kaplan-Meier method for patients with vaginal cuff recurrence, recurrence at another local or distant site, and those without evidence of recurrence. Comparisons were performed using the log-rank test. Cox proportional hazards regression model was performed to assess predictors of vaginal cuff recurrence. Results: From 469 women treated with radical cystectomy for bladder cancer, 34 patients (7.3%) developed vaginal cuff recurrence, 130 patients (27.7%) had recurrence involving either a local or distant site, and 305 patients (65%) had no evidence of recurrence. The 5-year overall mortality-free survival rate was 32.4% for vaginal cuff recurrence, but 25.0% for other sites of recurrence. Cancer-specific mortality-free survival rate was 32.4% for vaginal cuff recurrence, and 30.3% for the other sites of recurrence. Multivariate Cox proportional hazards regression analysis demonstrated that the presence of tumor in posterior location at radical cystectomy (Hazard Ratio [HR], 0.353 [95% CI, 0.159-0.783]) and anterior vaginectomy, compared to no vaginectomy (HR, 2.595 [95% CI, 1.077-6.249]) were independently associated with vaginal cuff recurrence. Conclusion: Anterior vaginectomy, despite our best attempts, is perhaps not sufficient to prevent vaginal cuff recurrence. Therefore, follow-up evaluation is essential, and further studies are necessary to address the optimal approach for initial management. Patient Summary: Although vaginal cuff recurrence is an unusual site of recurrence, careful evaluation is needed before cystectomy and during follow-up to identify patients at risk. Keywords: Urinary Bladder Neoplasms; Female; Neoplasm Metastasis; Recurrence [Full Text] Related Post Comparison of Gleason upgrading rates in transrectal ultrasound system... views 197 Simplified method using kidney / ureter / bladder x-ray to determine t... views 97 Effects of nitric oxide inhibitors in mice with bladder outlet obstruc... views 125 99mTc-DTPA Diuretic Renography with 3 hours late output fraction in th... views...

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PCA3 rs544190G>A and prostate cancer risk in an eastern Chinese population

Vol. 44 (3): 500-505, May – June, 2018 doi: 10.1590/S1677-5538.IBJU.2017.0146 ORIGINAL ARTICLE Dalong Cao 1, 2, Chengyuan Gu 1, 2, Dingwei Ye 1, 2, Bo Dai 1, 2, Yao Zhu 1, 2 1 Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China; 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China ABSTRACT Background: The association of prostate cancer antigen 3 (PCA3) polymorphism (SNP, rs544190G>A) with metastatic prostate cancer in European descent has been reported. Our aim of the current study was to re-validate the effect of PCA3 polymorphism on prostate cancer risk in an Eastern Chinese population and then estimate possible genetic discrepancies among population. Materials and Methods: Taqman assay was employed to determine genotype of SNP rs544190 in 1015 ethnic Han Chinese patients with prostate cancer and 1032 cancerfree controls. Simultaneously, odds ratios (OR) and 95% confidence intervals (95%CI) for risk relationship were calculated by logistic regression models. Results: The statistically significant relationship between PCA3 rs544190G>A and higher prostate cancer risk was not found. Stratification analysis revealed that there was no remarkable association of rs544190 variant AG/AA genotype with prostate cancer risk in every subgroup, except for patients with Gleason score ≤7(3+4). Conclusion: Although the results demonstrated that SNP rs544190 was not involved in prostate cancer risk in Eastern Chinese descent, unlike in European population, these might have clinical implications on prostate cancer heterogeneity around the World. To validate these findings, well-designed studies with different ethnic populations are warranted. Keywords: Prostatic Neoplasms; prostate cancer antigen 3, human [Supplementary Concept]; Polymorphism, Single Nucleotide [Full Text]   Related Post Clinical and pathologic factors predicting reclassification in active ... views 344 Complications after prone PCNL in pediatric, adult and geriatric patie... views 185 Ureteroscopy and stone treatment in the elderly (≥70 years): prospecti... views 294 Changing bulking agent may require change in injection volume for endo... views...

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Nephrogenic adenoma of the bladder: a single institution experience assessing clinical factors

Vol. 44 (3): 506-511, May – June, 2018 doi: 10.1590/S1677-5538.IBJU.2017.0155 ORIGINAL ARTICLE Yooni Yi 1, Angela Wu 2, Anne P. Cameron 1 1 Deparment of Urology and 2 Deparment of Pathology, University of Michigan, Michigan, USA ABSTRACT Introduction: Nephrogenic adenoma (NA) was first described by Davis in 1949 as a “hamartoma” of the bladder. There are many proposed predisposing factors for NA in­cluding chronic inflammation, renal transplantation, and bladder cancer. We examined our experience with NA to determine predisposing factors and determine if there was any increased risk for development of subsequent malignancy. Materials and Methods: All patients with a pathologic diagnosis of bladder NA from 2001-2013 were included. Patient history, clinical factors including possible predispos­ing factors for NA, and follow-up were reviewed. Results: Among 60 patients, 68% were males with an average age of 61, an average BMI of 28.7, and 60% had a smoking history. In evaluating pro-inflammatory factors, 26.7% underwent either Bacillus Calmette-Guerin or mitomycin C, 30% had recurrent urinary tract infections, and 25% had a history of catheterization. Recurrence of NA after initial resection occurred only in 14.7% of patients who underwent follow-up cystoscopy. A history of concurrent bladder cancer was seen in 41.7% of patients, but there were no cases of de novo bladder cancer diagnosed after NA. Conclusion: To the best of our knowledge, this is the largest series of patients with NA of the bladder. NA occurs in a heterogeneous population of patients, but most often with underlying inflammation. NA occurred concurrent with bladder cancer; however there were no cases of de novo bladder cancer after NA, reassuring that NA is likely a benign reactive condition.  Keywords: Urinary Bladder Neoplasms; Adenoma; Urologic Diseases [Full Text] Related Post Effects of Copaiba oil in the healing process of urinary bladder in ra... views 144 Vitamin C inhibits crystallization of struvite from artificial urine i... views 206 Predicting outcomes in partial nephrectomy: is the renal score useful? views 178 Validation of self – confidence scale for clean urinary intermit... views...

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Differences in the percutaneous nephrolithotomy practice patterns among Latin American urologists with and without endourology training

Vol. 44 (3): 512-523, May – June, 2018 doi: 10.1590/S1677-5538.IBJU.2017.0599 ORIGINAL ARTICLE Braulio O. Manzo 1, Edgar Lozada 1, Fabio C. Vicentini 2, Francisco Javier Sanchez 3, Gildardo Manzo 1 1 Hospital Regional de Alta Especialidade do Bajío, México; 2 Hospital das Clínicas da universidade de São Paulo, São Paulo, SP, Brasil; 3 Centro de Urologia do México (UROCEM), México ABSTRACT Purpose: Although the worldwide percutaneous nephrolithotomy (PCNL) practice patterns determined via a survey sent to members of the Endourological Society have been published, differences in PCNL practice patterns among Latin American urologists based on endourological or lithiasis training have not been published. To determine the PCNL practice patterns among Latin American urologists with and without training in endourology. Materials and Methods: The SurveyMonkey® web platform was used to develop a 27- item survey on PCNL for the treatment of renal stones, and the survey was sent via e-mail and other electronic media to 2000 urologists from 15 Latin American countries. Endourology-trained (group 1) and nontrained urologists (group 2) were analyzed. The group results were compared using the chi-squared and Fisher’s exact tests. SPSS version 20 for Windows was used for all analyses. Results: A total of 331 urologists responded to the survey (rate of 16.55%): 221 (66.7%) in group 1 and 110 (33.2%) in group 2). In groups 1 and 2, 91.9% and 63.2% performed PCNL, respectively; 85.1% and 58.5% used preoperative tomography, respectively; 12.7% and 4.7% used preoperative nephrolitometry nomograms, respectively; 45.2% and 32.1% used endoscopic combined intrarenal surgery, respectively; 68.3% and 38.7% used mul­tiple percutaneous tract realization, respectively; and 19.9% and 5.7% used minimally invasive PCNL, respectively (all p=0.0005). Conclusions: Statistically significant differences were observed in PCNL practice patterns of Latin American urologists with and without training in endourology. Specific training in endourology significantly influence the practice patterns of Latin American urologists. Keywords: Nephrolithotomy, Percutaneous; Health Care Surveys; Kidney Calculi [Full Text]   Related Post Urological myriad views 165 Validation of the urgency questionnaire in Portuguese: A new instrumen... views 165 Dramatic polarization in genitourinary expert opinions regarding the c... views 77 Editorial Comment: The protective effect of Papaverine and Alprostadil... views...

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Ureteral access sheaths: a comprehensive comparison of physical and mechanical properties

Vol. 44 (3): 524-535, May – June, 2018 doi: 10.1590/S1677-5538.IBJU.2017.0575 ORIGINAL ARTICLE Nishant Patel 1, Manoj Monga 1 1 Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, USA ABSTRACT Introduction: Ureteral access sheaths (UAS) facilitate flexible ureteroscopy in the treatment of urolithiasis. The physical properties of UAS vary by manufacturer and model. We compared three new UAS: Glideway (GW, Terumo, 11/13Fr, 12/14Fr), Pathway (PW, Terumo 12/14F) and Navigator HD (NHD, Boston Scientific, 11/13Fr, 12/14Fr) in the domains of safety characteristics, positioning characteristics, lubricity and radioopacity. Materials and Methods: In vitro testing of the three UAS included safety testing- tip perforation force, sheath edge deformation and dilator extraction forces. Positioning characteristics tested included tip bending, stiffness (resistance to coaxial buckling forces), kinking (resistance to perpendicular forces), and insertion forces. Lubricity was assessed by measured frictional forces of the outer sheath. Finally, radio-opacity was tested utilizing fluoroscopic imaging of the three 12F sheaths and inner dilators. Results: The PW (0.245 lb) and GW (0.286 lb) required less force for tip perforation compared to the NHD (0.628 lb). The NHD sheath edge deformation was mild compared to more severe deformation for the PW and GW. The PW (1.008 lb) required greater force than the GW (0.136 lb) and NHD (0.043 lb) for inner dilator removal. The GW (3.69 lbs) and NHD (4.17 lb) had similar inner dilator tip stiffness when bent, while the PW had the weakest inner dilator tip, 1.91 lbs. The PW (0.271 lb) was most susceptible to buckling and kinking (1.626 lb). The most lubricious UAS was the NHD (0.055 lbs for 12F). The NHD (0.277 lbs) required the least insertional force through a biological model and possessed the greatest radio-opacity. Conclusions: Comparison of different commercially available UAS in various sizes reveals that there are mechanical differences in sheaths that may play a role clinically. The Terumo sheaths’ (GW and PW) were outperformed by the Boston Scientific NHD in simulating safety, ease of use and radio-opacity. Keywords: Ureteroscopy; Ureter; instrumentation [Subheading] [Full Text]   Related Post Synchronous abdominal tumors: is combined laparoscopic surgery in a si... views 139 Flexible ureterorenoscopy is associated with less stone recurrence rat... views 180 Schooling impacts on the overactive bladder diagnosis in women views 274 The impact of metformin use on the risk of prostate cancer after prost... views...

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Evaluation of urodynamic parameters after sling surgery in men with post-prostatectomy urinary incontinence

Vol. 44 (3): 536-542, May – June, 2018 doi: 10.1590/S1677-5538.IBJU.2017.0243 ORIGINAL ARTICLE Odair Gomes Paiva 1, João Paulo Cunha Lima 1, Carlos Alberto Bezerra 1 1 Disciplina de Urologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil   ABSTRACT Objective: To evaluate urodynamic alterations after sub-urethral sling surgery (SSU) in patients with post-prostatectomy urinary incontinence (PPUI). Materials and Methods: We evaluated data of 22 patients submitted to radical prosta­tectomy (RP) or transurethral resection of prostate (TURP) that presented post-surgical urinary incontinence and were treated with SSU implant in a pilot study previously performed in our institution. Methods: Those patients with PPUI were evaluated by urodynamic exam (UD) before and after surgery, and the parameters were compared, including uroflow, cystometry and micturition study. Exclusion criteria included patients without pre-operatory uro­dynamic study, those with urethral stenosis, those not healed of prostate cancer, pa­tients without clinical conditions to be submitted to urodynamic study and those with severe neurological diseases or that refused to sign the consent form. Results were analyzed statistically by Fisher, Wilcoxon or Mann-Whitney tests. Results: During free uroflow, none parameters showed any statistical significant differences. During cystometry, there were also no statistical differences and the same was observed at pressure versus flow study; the exception was at maximal flow detrusor pressure (PdetQmax), that was lower at post-operatory (p=0.028). In relation to the presence of urinary dysfunctions associated to PPUI, we observed a significant reduc­tion of detrusor overactivity (p=0.035) in relation to pre-operatory period. Conclusion: SSU surgery significantly reduced detrusor overactivity and PdetQMax; however, there were no alterations of other evaluated urodynamic parameters. Keywords: Suburethral Slings; Surgical Procedures, Operative; Urinary Incontinence [Full Text]   Related Post Validation of preoperative variables and stratification of patients to... views 276 Effect of tadalafil 5mg daily treatment on the ejaculatory times, lowe... views 159 miR–483-5p promotes prostate cancer cell proliferation and invasion by... views 164 Stage effect of chronic kidney disease in erectile function views...

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Functional outcomes and quality of life after transobturatory slings: hand – made vs. commercial slings

Vol. 44 (3): 543-549, May – June, 2018 doi: 10.1590/S1677-5538.IBJU.2017.0524 ORIGINAL ARTICLE Danilo Budib Lourenço 1, Fernando Korkes 1, José Eduardo Vetorazzo Filho 2, Silvia da Silva Carramão 3, Antônio Pedro Flores Auge 3, Luis Gustavo Morato de Toledo 2 1 Departamento de Urologia, Hospital Israelita Albert Einstein, São Paulo, SP, Brasil; 2 Departamento de Urologia; 3 Departamento de Ginecologia, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil   ABSTRACT   Surgical correction is the most efficient treatment for stress urinary incontinence (SUI), and transobturator sling (TO) has optimal results. The high cost of commercially available sling kits makes it difficult the access in most Brazilian public health services. Hand-made polypropylene slings, on the other hand, have been previously reported. The aim of the present study was to compare the effectiveness and safety of commercial vs. hand-made polypropylene mesh slings. Data from 57 women who underwent consecutive TO sling surgery to treat SUI were pros­pectively collected between 2012 and 2014, and divided in two groups for further compa­rison. In Group-1, 31 women underwent surgery with commercial slings. In Group-2, 26 women underwent hand-made polypropylene slings. Women were compared according to epidemiological data, perioperative evaluation, quality of life, urodynamic study, cure and complication rates. Results were objectively (stress test with Valsalva maneuver, with at least 200mL vesical repletion) and subjectively evaluated by the Patient Global Impression of Improvement(PGI-I), Visual Analog Scale (VAS) and ICIQ-SF. Success was defined as PGI-I, VAS and negative stress test. Group-1 (n=31) and Group-2 (n=26) had a mean age of 60 vs. 58years (p=0.386). All de­mographic data were similar. The mean VLPP was 75.6cmH2O vs. 76.6cmH2O (p=0.88). The mean follow-up was 24.3 vs. 21.5months (p=0.96). Success rates were 74.2% vs. 80.2% (p=0.556), with ICIQ-SF variation of 12.6 vs.15.5 (p=0.139) and PGI-I of 71% vs. 80% (p=0.225). There was only one major complication (urethrovaginal fistula in Group-1). In conclusion, handmade and commercial slings have similar effectiveness and safety. The manufacture technique has important key-points stated in the present manuscript. Keywords: Urinary Incontinence, Stress; Pelvic Floor; Suburethral Slings [Full Text] Related Post Penile alterations at early stage of type 1 diabetes in rats views 128 Changes observed in prostate biopsy practices in an inner city hospita... views 168 Prostate Cancer – Local Treatment after Radiorecurrence: Surgery ̵... views 248 Validation of self – confidence scale for clean urinary intermit... views...

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Sexual complications of penile frature in men who have sex with men

Vol. 44 (3): 550-554, May – June, 2018 doi: 10.1590/S1677-5538.IBJU.2017.0520 ORIGINAL ARTICLE Rodrigo Barros 1, Gabriel Lacerda 1, Alex Schul 1, Paulo Ornellas 1, Leandro Koifman 1, Luciano A. Favorito 2, 3 1 Hospital Municipal Souza Aguiar, Rio de Janeiro, RJ, Brasil; 2 Universidade Estadual do Rio de Janeiro (UERJ), RJ, Brasil; 3 Hospital Federal da Lagoa, Rio de Janeiro, RJ, Brasil ABSTRACT   Objectives: Evaluate the demographic data, etiology, operative findings and results of surgical treatment of penile fracture (PF) in men who have sex with men(MSM) with emphasis on sexual complications. Materials and Methods: We studied 216 patients underwent surgical correction of PF at our hospital. Patients self-identified as MSM were followed for at least 6 months. Demographic data, presentation, operative findings, International Index of Erection Function – 5 (IIEF-5) and the Premature Ejaculation Diagnostic Tool. Results: Of 216 PF cases, 4 (1.8%) were MSM. All cases resulted from sexual activity and all patients reported using the “doggy style” position during anal intercourse. Unilateral or bilateral injury of corpus cavernosum was found in 2 patients each. One (25%) patient had complete urethral injury associated with bilateral corpus caverno­sum lesion. During the follow-up period, all patients developed some type of sexual complication. One patient reported penile pain during intercourse. Another patient experienced low sexual desire and premature ejaculation. This patient was also dis­satisfied with the aesthetic result of the surgical scar and complained about decreased penis size after surgery. The third case developed delayed ejaculation. The fourth pa­tient experienced mild to moderate erectile dysfunction. This same patient presented with penile curvature. Finally, palpable fibrotic nodules in the operative area were observed in all cases. Conclusions: Sexual activity in the “doggy style” position was the commonest cause of PF in MSM. Sexual dysfunction is always present in gay man after surgery for PF. However, additional studies with larger samples should be coinducted. Keywords: Penis; Homosexuality; Coitus [Full Text] Related Post Metastatic prostate cancer in the modern era of PSA screening views 142 Ureteral access sheaths: a comprehensive comparison of physical and me... views 258 miR–483-5p promotes prostate cancer cell proliferation and invasion by... views 164 Oxidative stress in the bladder of men with LUTS undergoing open prost... views...

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Objective measurements of the penile angulation are significantly different than self-estimated magnitude among patients with penile curvature

Vol. 44 (3): 555-562, May – June, 2018 doi: 10.1590/S1677-5538.IBJU.2017.0418 ORIGINAL ARTICLE Giovanni Liguori 1, Andrea Salonia 2, Giulio Garaffa 3, Giovanni Chiriacò 1 , Nicola Pavan 1, Giorgio Cavallini 4, Carlo Trombetta 1 1 Department of Urology, University of Trieste, Trieste, Italy; 2 Department of Urology, Università Vita- Salute San Raffaele, Milan, Italy; 3 St Peter’s Andrology and the Institute of Urology, University College London Hospitals, London, UK; 4 Andrological Unit, Gynepro Medical Team; Bologna, Italy   ABSTRACT Introduction: The study was aimed to assess the presence of actual differences between the objective and the perceived magnitude of a curvature between patients affected by Peyronie’s disease (PD) and congenital penile curvature (CPC). Materials and Methods: Wee analysed a cohort of 88 consecutive patients seeking medi­cal help for either CPC or PD. All patients were invited to provide a self-made drawing of their penis in erection in order to obtain self-provided description of the deformity. An objective measurement of the deformity was also performed drawing two intersecting lines through the center of the distal and proximal straight section of the penile shaft. Results: Our findings showed significant differences between patient self-estimation and the objective measurements of the penile angulation performed by trained experts, with only 32% of patients correctly assessing their own curvature. Overall, patients tended to overestimate (56%) their degree of curvature, but the results are different in patients with PD than those with CPC. In the 60 men (68%) who did not accurately assess their curvature, PD patients generally overestimated their curvature versus CPC patients (67% vs 16%). On the contrary CPC patients underestimated their curvature compared to PD (42% vs. 4%). Conclusion: In order to improve patients’ satisfaction rates, the surgeon needs to take into consideration the patient’s perception of the deformity when planning the type of surgical correction. Keywords: Penile Induration; Penis; Penile Erection [Full Text]   Related Post Impact of PSA density of transition zone as a potential parameter in r... views 191 Comparison between multiparametric MRI with and without post – c... views 134 miR–483-5p promotes prostate cancer cell proliferation and invasion by... views 164 Towards development and validation of an intraoperative assessment too... views...

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