Renal capsule for augmentation cystoplasty in canine model: a favorable biomaterial?

Vol. 42 (2): 383-388, March – April, 2016

doi: 10.1590/S1677-5538.IBJU.2014.0680


ORIGINAL ARTICLE

Renal capsule for augmentation cystoplasty in canine model: a favorable biomaterial?

Mehdi Salehipour 1, Reza Mohammadian 1, Amir Malekahmadi 1, Massood Hosseinzadeh 2, Mahnaz Yadollahi 3, Mohammad Natami 1, Mahsa Mohammadian 1

1 Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran; 2 Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran; 3 Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


ABSTRACT

Purpose: To evaluate effectiveness of canine renal capsule for augmentation cystoplasty.
Materials and Methods: Ten adult dogs participated in this study. After induction of anesthesia each animal underwent bed side urodynamic study, bladder capacity and bladder pressure was recorded. Then via mid line incision abdominal cavity was entered, right kidney was identified and its capsule was dissected. Bladder augmentation was done by anastomosing the renal capsule to the bladder. After 6 months bed side urodynamic was performed again and changes in bladder volume and pressure were recorded. Then the animals were sacrificed and the augmented bladders were sent for histopathology evaluation.
Results: Mean maximum anatomic bladder capacity before cystoplasty was 334.00±11.40cc which increased to 488.00±14.83cc post-operatively (p=0.039). Mean anatomic bladder pressure before cystoplasty was 19.00±1.58cmH2O which decreased to 12.60±1.14cmH2O post-operatively (p=0.039). Histopathology evaluation revealed epithelialization of the renal capsule with urothelium without evidence of fibrosis, collagen deposits or contracture.
Conclusions: Our data shows that renal capsule is a favorable biomaterial for bladder augmentation in a canine model.

Keywords: Urinary Bladder; Dogs; Biocompatible Materials

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