Predictive role of Trimprob associated with multiparametric MRI in the diagnosis of prostate cancer

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Vol. 43 (1): 29-35, January – February, 2017

doi: 10.1590/S1677-5538.IBJU.2015.0714


ORIGINAL ARTICLE

Gustavo Cardoso Guimaraes 1, Walter Henriques da Costa 1, Renato Almeida Rosa 1, Stênio Zequi 1, Ricardo Favaretto 1

1 Núcleo de Urologia, Departamento de Cirurgia Pélvica, AC Camargo Cancer Center, SP, Brasil

ABSTRACT

Objectives: to evaluate the predictive value of TRIMprob test to detect prostate cancer (PCa) in patients referred to prostate biopsy (PB).
Material and Methods: Patients with PSA <10ng/mL and rectal exam without findings suggestive of prostate cancer were selected for TRIMprob evaluation.
Exam was performed by a single operator through transperineal approach.
Patients admitted for the study were submitted to TRIMprob and multiparametric magnetic resonance (mpMRI) and posteriorly to PB.
Results: In total, 77 patients were included. TRIMprob showed evidences of PCa in 25 (32.5%) and was negative in 52 patients (67.5%). The rate of detection of prostate cancer at biopsy was higher in patients with positive TRIMprob (16/25; 64.0%) than in patients with negative TRIMprob (11/52; 21.1%; p<0.001). Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of TRIMprob were respectively 61.5%, 82.0%, 64.0%, 80.3% and 74.0%. ROC curve showed the following areas under the curve values for TRIMprob, mpMRI and combination of TRIMprob + mpMRI: 0.706; 0.662 and 0.741 respectively. At combined analysis, when both TRIMprob and mpMRI were negative for prostate cancer, accuracy was 96.3% or only 1 in 27 PB was positive (3.7%).
Conclusions: Trimprob had similar predictive value for PCa in patients submitted to PB as mpMRI. Combined TRIMprob and mpMRI showed higher accuracy than when performed singly.

Keywords: Magnetic Resonance Imaging; Prostatic Neoplasms; Diagnosis

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