Long-term response of different Botulinum toxins in refractory neurogenic detrusor overactivity due to spinal cord injury

Vol. 43 (4): 721-729, July – August, 2017

doi: 10.1590/S1677-5538.IBJU.2016.0584


Giuseppe Lombardi 1, Stefania Musco 1, Giovanni Bacci 2, Maria Celso 1, Valerio Bellio 1, Giulio Del Popolo 1
1 Department of Neuro-Urology, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy; 2 Department of Biology, Universita Degli Studi di Firenze, Toscana, Italy



Purpose: To assess the response in spinal cord injured patients alternatively treated with different types and dosages of Botulinum neurotoxin type A (BoNT/A) over 15 years.

Material and methods: Patients who underwent first BoNT/A from 1999-2001 and prac­ticed intermittent catheterization were included. Baseline 3-day bladder diary (BD) and urodynamics were collected. BoNT/A failure was defined when patients asked for re-injection ≤ 3 months post-treatment. Criteria for re-injection was at least one daily epi­sode of urinary incontinence at BD. Before re-injection, patients were asked if they had reached 6 months of dryness without antimuscarinics (YES response).

Results: Overall, 32/60 (53.4%) “No failure” (NF) group; 16 (26.6%) “occasional failure” (OF) and 12 (20%) “consecutive failure” (CF) were included. A total of 822 BoNT/A infiltrations were performed. The mean interval from previous injection to treatment re-scheduling was 8 months. No significant differences between treatments were found within the three groups (p>0.05).

The percentage of YES responses increased from 19% (AboBoNT/A 500IU) to 29 % (OnaBoNT/A 300IU) in NF, and from 18% (AboBoNT/A 500IU) to 25% (OnaBoNT/A 300IU) for OF. Five NF cases (15.6%) maintained 6 months of dryness after each injec­tion. Among the baseline variables, only low compliance (< 20mL/cmH2O) was found as predictor for failure (p=0.006).

Conclusions: Long term BoNT/A for NDO did not increase failures, independent of the types of treatments and switching. Definition of failure and other criteria for continuing repetitive BoNT/A treatment is mandatory. CF was predictable for no response in earlier follow-up.

Keywords: Botulinum Toxins, Type A; Spinal Cord Compression; Urinary Bladder, Neurogenic

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