Efficacy of Tamsulosin, Oxybutynin, and their combination in the control of double-j stent-related lower urinary tract symptoms

Vol. 42 (3): 487-493, May – June, 2016

doi: 10.1590/S1677-5538.IBJU.2015.0186


ORIGINAL ARTICLE

Efficacy of Tamsulosin, Oxybutynin, and their combination in the control of double-j stent-related lower urinary tract symptoms

Miguel Maldonado-Avila 1, Leopoldo Garduño-Arteaga 1, Rene Jungfermann-Guzman 1, Hugo A. Manzanilla-Garcia 1, Emmanuel Rosas-Nava 1, Nestor Procuna-Hernandez 1, Alejandro Vela-Mollinedo 1, Luis Almazan-Treviño 1, Jose Guzman-Esquivel 2
1 Departamento de Urologia, Hospital Geral de Mexico, Ciudad de Mexico, 2 Instituto Mexicano del Seguro Social Colima, no México
ABSTRACT

Introduction and objective: Indwelling double J ureteral stents are used routinely in the resolution of ureteral obstruction caused by different etiologies. Evaluation of urinary symptoms related to double-J stent, indicate that these affect 73-90% of patients.
We conducted a prospective, randomized study, to evaluate the efficacy of tamsulo¬sin, oxybutinin and combination therapy in improving the urinary symptoms.
Methods: Patients who underwent ureteral stent placement after ureterolithotripsy (total 51), were randomized into three groups: Group I: Tamsulosin 0.4 mg. once per day(17 patients), Group II: Oxybutinin 5 mg. once per day (17 patients), Group III: Tamsulosin+ oxybutynin once per day (17 patients). All the groups received the drugs for three weeks and completed a Spanish validated Ureteral Stent Symptom Questionnaire (USSQ) at day 7 and 21.
Results: Repeated measures ANOVA showed mean urinary symptom index score was 22.3 vs. 15.5 in group three (p<0.001) at day 7 and 21 respectively. The mean work performance index was 6.6 vs 8.1 (p=0.049) favoring tamsulosin group, the mean sexual score was 0.5 vs 1.5 (p=0.03). Among additional problems the mean was 7.2 vs 6.2 (p=0.03). No significant difference was noted among pain and general health index. No side effects were reported.
Conclusions: Combination therapy with tamsulosin and oxybutynin improved irri¬tative symptoms and work performance as well as sexual matters. Combination the¬rapy should be considered for patients who complained of stent related symptoms.

Keywords: tamsulosin [Supplementary Concept]; oxybutynin [Supplementary Concept]; Lower Urinary Tract Symptoms

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