Effects of Copaiba oil in the healing process of urinary bladder in rats

Vol. 43 (x): 2017 August 8.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2017.0143


Denilson José Silva Feitosa Junior 1, Luan Teles Ferreira de Carvalho 1, Ingrid Rodrigues de Oliveira Rocha 1, Camila Noura de Brito 1, Rodrigo Alencar Moreira 2, Carlos Alberto Villacorta de Barros 3
1 Laboratório de Cirurgia Experimental, Universidade Estadual do Pará, Belém, PA, Brasil; 2 Departamento de Pesquisa Cirúrgica e Experimental, Universidade Estadual do Pará, Belém, PA, Brasil; 3 Departamento de Cirurgia Experimental e Anestesiologia, Universidade Estadual do Pará, Belém, PA, Brasil



Introduction: The appropriate closure of the urinary bladder is important to many uro­logic procedures to avoid the formation of fistulas and strictures by excessive fibrosis. This paper presents the alterations in the bladder healing process of rats after the topi­cal use of Copaiba oil (Copaifera reticulata).

Material and Methods: Ten male Wistar rats were used and randomly divided into two groups: Control group (CG): injected 1ml/kg of saline solution on the suture line; and Copaiba group (CpG): 0.63ml/kg of copaiba oil applied to the suture line. Euthanasia was performed on the seventh day after surgery. The criteria observed were adherences formation, histopathological modifications and stereology for collagen.

Results: Both groups showed adhesions to the bladder, with no statistically significant difference (p=0.1481). The microscopic evaluation revealed a trend to more severe acute inflammation process on the CpG, but there was statistical difference only in the giant cells reaction (p=0.0472) and vascular proliferation (p=0.0472). The stereology showed no difference.

Conclusion: The copaiba oil modified the healing process, improving the quantity of giant cells and vascular proliferation, but not interfered in the collagen physiology.

Keywords: Urinary Bladder; Wound Healing; Plants, Medicinal; Collagen

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