Effectiveness and durability of solifenacin versus percutaneous tibial nerve stimulation versus their combination for the treatment of women with overactive bladder syndrome: a randomized controlled study with a follow-up of ten months

 Vol. 43 (x): 2017 August 8.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2016.0611


Carlo Vecchioli-Scaldazza 1, Carolina Morosetti 2
1 Division of Urogynecology, ASUR, Jesi, Italy; 2 Clinical Pathology, ASUR, Jesi, Italy


Purpose: To assess effectiveness and durability of Solifenacin (SS) versus tibial nerve stimulation (PTNS) versus combination therapy (PTNS + SS) in women with overactive bladder syndrome (OAB).

Materials and Methods: 105 women with OAB were divided randomly into three groups of 35 patients each. In group A women received SS, in group B women under­went PTNS, in group C women underwent combination of PTNS + SS. Improvements in OAB symptoms were assessed with OABSS questionnaire; patients’ quality of life was assessed with OAB-q SF questionnaire. Evaluation of effectiveness of treatments was performed with PGI-I questionnaire. OABSS and PGI-I were also assessed monthly for ten months.

Results: All treatments were effective on symptoms. PTNS showed a greater effective­ness than SS, but PTNS + SS was more effective than SS and PTNS. Furthermore, PTNS + SS showed a greater duration of effectiveness than PTNS and SS.

Conclusions: Combination of PTNS with SS showed more effectiveness and more du­rability than PTNS and SS alone.

Keywords:  Urinary Bladder, Overactive; Combined Modality Therapy; Solifenacin Succinate

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