Cystometric analysis of the transplanted bladder

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Vol. 43 (1): 112-120, January – February, 2017

doi: 10.1590/S1677-5538.IBJU.2015.0117


ORIGINAL ARTICLE

Jeová Nina Rocha 1

1 Departamento de Urologia Hospital das Clínicas da FMRP-USP Ribeirão Preto, São Paulo, Brasil

ABSTRACT

Objective: cystometric evaluation of the bladder after autotransplant and isogeneic transplant in female rats.

Material and Methods: two groups were constituted: (A) bladder autotransplant with two subgroups: R1 – (control) and R2 – (bladder transplant); (B) isogeneic bladder transplant with three subgroups; T1 – (control); T2–T3, two subgroups observed for 30 and 60 days after transplant, respectively. All animals underwent cystometric evalua­tion. Afterwards, the bladders were removed for histological study.

Results: the transplanted bladders did not show significant changes in filling/storage and emptying/micturition functions after 30 and 60 days of evolution. Upon macros­copical evaluation, there was good revascularization and the tissue was well preserved. Cystometry results: did not show significant differences in the micturition pressure in subgroups T2-T3, but did between subgroups R1−R2, T1−T2, and T1−T3. Significant differences were verified in the micturition interval between T1−T3, T2−T3, but not between R1−R2, T1−T2. There was significant difference in the micturition duration between T1−T3 but not between R1−R2, T1−T2 and T2−T3. No fistula was noted on the suture site nor leakage of urine in the abdominal cavity or signs of necrosis or retraction were observed.

Conclusions: transplant of the bladder was shown to be a viable procedure. The results indicate that there was structural and functional regeneration of transplanted bladders, and these results indicate that it is possible that vascular endothelium growth and neurogenesis factors are involved and activated in the process of the preservation or survival of the transplanted organ.

 Keywords:  Transplantation; Urinary Bladder; Patients

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