Clinical Significance of Preoperative Neutrophil – to – Lymphocyte Ratio in Renal Cell Carcinoma

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Vol. 42 (4): 678-684, July – August, 2016

doi: 10.1590/S1677-5538.IBJU.2015.0397


Alper Otunctemur 1, Murat Dursun 1, Huseyin Besiroglu 1, Kutan Ozer 2, Ozan Horsanali 2, Emin Ozbek 1

1 Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey; 2 Department of Urology, Ataturk Training and Research Hospital, Izmir, Turkey


Introduction: We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio on tumor stage and Fuhrman nuclear grade in renal cell carcinoma.
Methods: The records of 432 patients with RCC who underwent radical or partial nephrectomy between 2005 and 2014 were retrospectively reviewed. Patients were classified as group lower tumor stage (T1 + T2) and higher (T3 + T4). As like tumor stage, Fuhrman nuclear grade were classified lower (G1+G2) and higher (G3+G4) too. The best NLR cut off value was 3.01.Two sample t-test or Mann–Whitney U-test used for the continuous variables and a chi-square test or Fisher’s exact test used for the categorical variables.
Results: Among the 432 total patients analyzed in our study, there were 275 males (63.7%) and 157 females (36.3%). Mean laboratory values were CRP 2.73 ± 1.93 mg/ dL (normal less than 0.3), neutrophil count 4.23 ± 1.46/μL, lymphocyte count 1,61 ± 0.61/μL and NLR 2.64 ± 1.24. According to our data, statistically pretreatment NLR significantly
correlated with CRP (p<0.0001). And tumor patologic stage(p=008), tumor histologic grade (p<0.001) was significantly associated with NLR.
Discussion: We compared the relationship of preoperative NLR and NC parameters with RCC tumor stage and grade. And NLR were found to have statistically significant higher T stage and grade at RCC. Further studies with more patients are needed to confirm our study.

Keywords: Neutrophils; Lymphocytes; Carcinoma, Renal Cell; Epithelium

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