Current Issue

Volume 44 | number 3 | May . June, 2018 – Urological myriad – The internationality and diversity of subjects have been remarkable characteristics of International
Braz J Urol, an open free access urological journal, as is this issue

Urological myriad

Vol. 44 (3): 420-421, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2018.03.01


EDITORIAL In this issue

Stênio de Cássio Zequi 1
1 Divisão de Urologia do A.C. Camargo Cancer Center Fundação A. Prudente, São Paulo, Brasil

The internationality and diversity of subjects have been remarkable characteristics of International Braz J Urol, an open free access urological journal, as is this issue.

Collaborative multicenter studies in Urology are lacking in Latin American; efforts in this way are welcome by International Braz J Urol. Colleagues from Mexican centers and Sao Paulo University (Manzo and Vicentini, respectively), found differences in the management of kidney stones with percutaneous nephrolitotomy when compared trained and non-trained urologists. In that survey, they evaluated data from 331 urologists from 15 Latin American countries, that answered a 27-item questionnaire, easily accessed by mobile phones. Patel and Monga, from Cleveland Clinic, present in this issue, the distinct physical and mechanical properties of different ureteral sheaths, that are commercially used in their country, reiterating the possible impact in clinical practice.

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Related Post

Network meta-analysis, a new statistical technique at urologists’ disposal to improve decision making

Vol. 44 (3): 422-428, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2018.03.02


EDITORIAL


Herney Andres Garcia-Perdomo 1, 2
1 Universidad del Valle, Cali, Colombia, CO; 2 Urological Research Group, UROGIV, Cali, Colombia, CO

INTRODUCTION

Systematic reviews have been determined to be fundamental tools for establishing the magnitude of an effect, with adequate rigor, methodology and scientific quality (1-4). A meta-analysis is a statistical analysis used in medical investigation, to synthesize information, and compare at least two interventions at a time, regarding an appropriate investigative question (4). Additionally, the available comparisons have to be made, in at least two studies, between intervention A and B otherwise, it is not possible to make it; nonetheless we lack of studies which make all the possible comparisons feasible nowadays (5).

Due to the lack of direct evidence, tools as network meta-analysis and indirect comparisons have been developed, considering all the available studies, and allowing comparisons regarding a common element, to estimate the effect of an intervention in an indirect way (6, 7). Network meta-analysis has also been called multiple-treatment comparison or mixed-treatment comparison meta-analysis (8). The aim of this review is to expose the introductory concepts of network meta-analyses, and indirect comparisons.

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Related Post

Prostate Cancer – Local Treatment after Radiorecurrence: HIFU – High-Intensity Focused Ultrasound

Vol. 44 (3): 429-432, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2018.03.03


DIFFERENCE OF OPINION

Stenio de Cassio Zequi 1, Thiago Camelo Mourao 2, Gustavo Cardoso Guimaraes 1
1 Divisão de Urologia, AC Camargo Cancer Center, Fundação A. Prudente, São Paulo, SP, Brasil; 2 Departamento de Urooncologia, Laparoscopia e Robótica, AC Camargo Cancer Center, Fundação A. Prudente, São Paulo, SP, Brasil

Keywords: High-Intensity Focused Ultrasound Ablation; Prostatic Neoplasms; Radiotherapy


Currently, about one third of all newly diagnosed prostate cancer patients select radiotherapy or brachytherapy (BT) as their primary treatment (1). Primary external beam radiation therapy (EBRT) in localized prostate cancer has a risk of biochemical recurrence about 30-60% (1, 2). The most widely utilized criteria for EBRT biochemical relapse is the Phoenix definition (2006). It is established as a PSA elevation of ≥ 2 ng/mL above the nadir PSA (3).There are a variety of treatment options, like watchful waiting, androgen deprivation therapy (ADT) and local salvage therapies. None of them are accepted as gold standard salvage treatments. Another important point is that recurrences are associated with an increased risk of death, metastases and local complications, such as ureteral obstruction, hematuria and pelvic pain (1).

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Related Post

Prostate Cancer – Local Treatment after Radiorecurrence: Surgery – Back to the future?

Vol. 44 (3): 433-434, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2018.03.04


DIFFERENCE OF OPINION

Leonardo O. Reis 1,2 Paul L. Nguyen 3
1 Departamento de Oncologia Urológica (UroScience), Pontifícia Universidade Católica de Campinas, PUC – Campinas, SP, Brasil; 2 Universidade Estadual de Campinas, Unicamp, Campinas, SP, Brasil; 3 Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Keywords: Prostatic Neoplasms; Salvage Therapy; Radiation


As radiotherapy advances, inadequate deliveries decrease and salvage radical prostatectomy, when necessary, tends to be less challenging with improving oncological and functional results. It treats cancer foci in regions such as apex or periurethral tissue, often spared in ablative approaches to minimize side effects; adds the clear goal of an undetectable PSA; and the opportunity for pelvic lymph-node dissection to potentially treat loco regional micrometastasis.

Up to 50% of men may develop recurrence after definitive radiation for prostate cancer, and about one-third of these men will have a biopsy-proven local radiorecurrence, which occurs due to either inadequate delivery of the prescribed radiation dose or inherent biologic resistance of prostate cancer clones to radiation. Standard of care for these patients has been classically observation followed by androgen deprivation (ADT), which adds substantial morbidity and doesn’t offer the possibility of cure.

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Related Post

Prostate Cancer – Local Treatment after Radiorecurrence: Salvage Cryoablation

Vol. 44 (3): 435-439, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2018.03.05


DIFFERENCE OF OPINION

Rodrigo Donalisio da Silva1, 2, Fernando J. Kim 1,2
1 Division of Urology, Denver Health Medical Center, Denver, CO, USA; 2 Division of Urology, University of Colorado Denver, Denver, CO, USA

 


Keywords: Radiation; Prostatic Neoplasms; Radiotherapy

 


Radiation therapy (RT) is an effective treatment for localized prostate cancer and approximately 45% of patients diagnosed with localized prostate cancer choose radiotherapy as initial treatment (1). Novel RT technology is evolving, allowing more targeted and higher doses of radiation in the prostate such as three-dimensional conventional RT and intensity-modulated conformal RT.

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Related Post

Clinical and pathologic factors predicting reclassification in active surveillance cohorts

Vol. 44 (3): 440-451, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0320


REVIEW ARTICLE

Pablo S. Sierra 1, Shivashankar Damodaran 2, David Jarrard 2, 3
1 Fundacion Valle del Lili -Universidad Icesi, Cali, Colombia; 2 Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; 3 University of Wisconsin Carbone Cancer Center, Madison, WI, USA

ABSTRACT

The incidence of small, lower risk well-differentiated prostate cancer is increasing and almost half of the patients with this diagnosis are candidates for initial conservative management in an attempt to avoid overtreatment and morbidity associated with sur¬gery or radiation. A proportion of patients labeled as low risk, candidates for Active Surveillance (AS), harbor aggressive disease and would benefit from definitive treat¬ment. The focus of this review is to identify clinicopathologic features that may help identify these less optimal AS candidates.
A systematic Medline/PubMed Review was performed in January 2017 according to PRISMA guidelines; 83 articles were selected for full text review according to their relevance and after applying limits described.
For patients meeting AS criteria including Gleason Score 6, several factors can assist in predicting those patients that are at higher risk for reclassification including higher PSA density, bilateral cancer, African American race, small prostate volume and low testosterone. Nomograms combining these features improve risk stratification.
Clinical and pathologic features provide a significant amount of information for risk stratification (>70%) for patients considering active surveillance. Higher risk patient subgroups can benefit from further evaluation or consideration of treatment. Recom¬mendations will continue to evolve as data from longer term AS cohorts matures.

Keywords: Prostatic Neoplasms; Neoplasm Grading

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Related Post

On thin ice: barriers to adoption of surveillance for patients with stage I testicular seminoma. Survey of US radiation oncologists

Vol. 44 (3): 452-460, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0454


ORIGINAL ARTICLE

Aditya Jain 1,2, Catherine Degnin 2, Yiyi Chen 2, Mike Craycraft 3, Arthur Hung 2, Jerry Jaboin 2, Charles R. Thomas, Jr. 2, Timur Mitin 2
1 Boston University, Boston, MA, USA; 2 Oregon Health and Science University, Portland, OR, USA. 3 Testicular Cancer Society, Cincinnati, OH, USA

ABSTRACT

Purpose: Most men with stage I testicular seminoma are cured with surgery alone, which is a preferred strategy per national guidelines. The current pattern of practice among US radiation oncologists (ROs) is unknown.

Materials and Methods: We surveyed practicing US ROs via an online questionnaire. Respondent’s characteristics, self-rated knowledge, perceived patient compliance rates with observation were analyzed for association with treatment recommendations.

Results: We received 353 responses from ROs, of whom 23% considered themselves experts. A vast majority (84%) recommend observation as a default strategy, however this rate drops to 3% if the patient is believed to be noncompliant. 33% of respondents believe that survival is jeopardized in case of disease recurrence, and among these respondents only 5% support observation. 22% of respondents over-estimate the likeli­hood of noncompliance with observation to be in the 50-80% range. Responders with a higher perceived noncompliance rate are more likely to recommend adjuvant therapy (Fisher’s exact p<0.01). Only 7% of respondents recommend observation for stage IS seminoma and 45% administer adjuvant RT in patients with elevated pre-orchiectomy alpha-fetal protein levels.

Conclusions: Many US ROs over-estimate the likelihood that stage I testicular semi­noma patients will be noncompliant with surveillance and incorrectly believe that overall survival is jeopardized if disease recurs on surveillance. Observation is quickly dismissed for patients who are not deemed to be compliant with observation, and is generally not accepted for patients with stage IS disease. There is clearly an oppor­tunity for improved physician education on evidence-based management of stage I testicular seminoma.

Keywords: Seminoma; Chemotherapy, Adjuvant; Radiotherapy; Health Care Surveys

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Related Post

Can preoperative neutrophil lymphocyte ratio predict malignancy in patients undergoing partial nephrectomy because of renal mass?

Vol. 44 (3): 461-466, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0225


ORIGINAL ARTICLE

Sacit Nuri Gorgel 1, Kutan Ozer 1, Osman Kose 1, Ahmet Selçuk Dindar 1
1 Department of Urology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, , Izmir,Turkey

ABSTRACT

Purpose: To evaluate the importance of preoperative neutrophil lymphocyte ratio (NLR) predicting malignancy in patients who undergo partial nephrectomy due to renal mass.

Materials and Methods: Seventy nine patients who underwent open partial nephrec­tomy for renal masses were included in this retrospective study. In preoperative routine blood tests, renal ultrasonography and contrast-enhanced computed tomography were performed for all patients. Preoperative neutrophil lymphocyte ratio were compared in patients with clear cell renal cell carcinoma (Group1, 65 patients) and benign lesions (Group 2, 14 patients). The predictive ability of NLR was analyzed by ROC curves and Youden Index method was used to identify the cut-off value for NLR.

Results: The mean age of patients was 59.8±11.7 years in Group1 and 57.4±12.6 years in Group 2 (p=0.493). The mean tumor size was 3.8±1.2 cm in Group 1 and 3.3±1.0 cm in Group 2 (p=0.07). The median NLR was 2.48 (1.04) in Group 1 and 1.63 (0.96) in Group 2 (p<0.001). The area under a ROC curve was 0.799 (p<0.001).

Conclusions: Preoperative neutrophil lymphocyte ratio may predict renal masses that can not be distinguished radiologically. Our results must be confirmed by large and properly designed prospective, randomized trials.

Keywords: Carcinoma, Renal Cell; Neutrophils; Lymphocytes

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Related Post

Comparison of perioperative outcomes with or without renorrhaphy during open partial nephrectomy: A propensity score-matched analysis

Vol. 44 (3): 467-474, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2016.0581


ORIGINAL ARTICLE

Hidekazu Tachibana 1, Toshio Takagi 1, Tsunenori Kondo 1, Hideki Ishida 1, and Kazunari Tanabe 1
1 Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan

ABSTRACT

Purpose: Renorrhaphy in partial nephrectomy may damage intraparenchymal vessels and compress the renal parenchyma, which may lead to the formation of renal artery pseudoaneurysms or vascularized parenchymal volume reduction. Using propensity score matching, we compared surgical outcomes following non-renorrhaphy and renorrhaphy techniques for open partial nephrectomy (OPN) for T1a renal tumors.

Materials and Methods: We retrospectively analyzed data from 159 patients with normal contralateral kidneys who underwent OPN for T1a renal tumors and pre- and postoperative enhanced computed tomography between 2012 and 2015. Patient variables were adjusted using 1:1 propensity score matching between the two Groups: renorrhaphy (inner and outer layer sutures) and non-renorrhaphy (inner layer sutures only). Postoperative complications and renal function were compared between the two groups.

Results: We matched 43 patients per Group. Operative time, estimated blood loss, cold ischemic time, and postoperative hospital stay were not significantly different between the two Groups. Urine leakage (Clavien-Dindo grade ≥3) occurred in 0 renorrhaphy cases and 2 non-renorrhaphy cases (0% versus 4.6%, P=0.49). Renal artery pseudoaneurysm (RAP) occurred in 6 renorrhaphy cases and in 0 non-renorrhaphy cases (13% versus 0%, P=0.02).

Conclusions: The non-renorrhaphy technique may result in a lower risk of RAP but a greater risk of urine leakage. This technique needs further refinement to become a standard procedure for OPN.

Keywords: Complications, non-renorrhaphy, partial nephrectomy, renal cell carcinoma, renal function

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Related Post

Positive surgical margins are predictors of local recurrence in conservative kidney surgery for pT1 tumors

Vol. 44 (3): 475-482, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0039


ORIGINAL ARTICLE

Patricio Garcia Marchiñena 1, Sebastián Tirapegui 1, Ignacio Tobia Gonzalez 1, Alberto Jurado 1, Guillermo
Gueglio 1
1 Department of Urology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

ABSTRACT

Objectives: The clinical significance of positive surgical margin (PSM) after a Nephron Sparing Surgery (NSS) is controversial. The aim of this study is to evaluate the association between PSM and the risk of disease recurrence in patients with pT1 kidney tumors who underwent NSS.

Materials and Methods: Retrospective cohort study. A total of 314 patients submitted to a NSS due to stage pT1 renal tumor between January 2010 and June 2015 were included. Recurrence-free survival was estimated. The Cox model was used to adjust the tumor size, histological grade, pathological stage, age, surgical margins and type of approach.

Results: Overall PSM was 6.3% (n=22). Recurrence was evidenced in 9.1% (n=2) of patients with PSM and 3.5% (n=10) for the group of negative surgical margin (NSM).

The estimated local recurrence-free survival rate at 3 years was 96.4% (95% CI 91.9 to 100) for the NSM group and 87.8% (95% CI 71.9 to 100) for PSM group (p=0.02) with no difference in metastasis-free survival. The PSM and pathological high grade (Fuhrman grade III or IV) were independent predictors of local recurrence in the multivariate analysis (HR 12.9, 95%CI 1.8-94, p=0.011 / HR 38.3, 95%CI 3.1-467, p=0.004 respectively). Fuhrman grade proved to be predictor of distant recurrence (HR 8.1, 95%CI 1.6-39.7, p=0.011).

Conclusions: The PSM in pT1 renal tumors showed to have higher risk of local recurrence and thus, worse oncological prognosis.

 

Keywords: Kidney; Surgical Procedures, Neoplasms; Prognosis

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Related Post

Synchronous abdominal tumors: is combined laparoscopic surgery in a single approach a safe option?

Vol. 44 (3): 483-490, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0429


ORIGINAL ARTICLE

Marcelo Cartapatti 1, Roberto Dias Machado 1, Roberto Lodeiro Muller 1, Wesley J. Magnabosco 1, Alexandre César Santos 1, Brian Francis Chapin 2, Armando Melani 1, Antonio Talvane 1, Marcos Tobias-Machado 3, Eliney Ferreira Faria 1
1 Hospital de Câncer de Barretos, Barretos, SP, Brasil; 2 MD Anderson Cancer Center, Houston, TX, USA; 3 Faculdade de Medicina do ABC, Santo André, SP, Brasil

 

ABSTRACT  

Background and Purpose: Recent advances in cancer treatment have resulted in bet­ter prognosis with impact on patient’s survival, allowing an increase in incidence of a second primary neoplasm. The development of minimally invasive surgery has provided similar outcomes in comparison to open surgery with potentially less mor­bidity. Consequently, this technique has been used as a safe option to simultaneously treat synchronous abdominal malignancies during a single operating room visit. The objective of this study is to describe the experience of two tertiary cancer hospitals in Brazil, in the minimally invasive treatment of synchronous abdominal neoplasms and to evaluate its feasibility and peri-operative results.

Materials and Methods: We retrospectively reviewed the data from patients who were submitted to combined laparoscopic procedures performed in two tertiary hospitals in Brazil from May 2009 to February 2015.

Results: A total of 12 patients (9 males and 3 females) with a mean age of 58.83 years (range: 33 to 76 years) underwent combined laparoscopic surgeries for the treatment of at least one urological disease. The total average duration of surgery was 339.8 minutes (range: 210 to 480 min). The average amount of intraoperative bleeding was 276.6mL (range: 70 to 550mL) and length of hospitalization was 5.08 days (range: 3 to 10 days). Two patients suffered minor complications regarding Clavien system during the immediate postoperative period.

Conclusions: Combined laparoscopic surgery for the treatment of synchronous tumors is feasible, viable and safe. In our study, there was a low risk of postoperative morbidity.

 Keywords: Laparoscopy; Neoplasms; Neoplasms, Multiple Primary

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Related Post

Vaginal cuff recurrence after radical cystectomy: an under – studied site of bladder cancer relapse

Vol. 44 (3): 491-499, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0376


ORIGINAL ARTICLE

Fabio Zattoni 1, 2, Alessandro Morlacco 1, 2, Avinash Nehra 1, Igor Frank 1, Stephen A. Boorjian 1, Prabin Thapa 3, R. Jeffrey Karnes 1
1 Department of Urology, Mayo Clinic, Rochester, Minnesota, USA; 2 Clinica Urologica, Dipartimento di scienze Chirurgiche, Oncologiche e Gastroenterologiche, Azienda Ospedaliero – Universitaria di Padova, Padova, Italy; 3 Health Sciences Research, Mayo Clinic, Rochester, MN, USA

ABSTRACT

Introduction: Vaginal cuff recurrence of tumor following radical cystectomy is a rare site of disease recurrence, however it has never been specifically studied. The aim of the study is to evaluate incidence, risk factors, and long-term oncologic outcomes of vaginal cuff recurrence in a cohort of female patients treated with radical cystectomy for invasive urothelial carcinoma of the bladder.

Materials and Methods: From 1985 to 2012, a prospectively maintained institutional bladder cancer registry was queried for vaginal cuff recurrence post radical cystectomy. Overall mortality and cancer-specific mortality were reported using the Kaplan-Meier method for patients with vaginal cuff recurrence, recurrence at another local or distant site, and those without evidence of recurrence. Comparisons were performed using the log-rank test. Cox proportional hazards regression model was performed to assess predictors of vaginal cuff recurrence.

Results: From 469 women treated with radical cystectomy for bladder cancer, 34 patients (7.3%) developed vaginal cuff recurrence, 130 patients (27.7%) had recurrence involving either a local or distant site, and 305 patients (65%) had no evidence of recurrence. The 5-year overall mortality-free survival rate was 32.4% for vaginal cuff recurrence, but 25.0% for other sites of recurrence. Cancer-specific mortality-free survival rate was 32.4% for vaginal cuff recurrence, and 30.3% for the other sites of recurrence. Multivariate Cox proportional hazards regression analysis demonstrated that the presence of tumor in posterior location at radical cystectomy (Hazard Ratio [HR], 0.353 [95% CI, 0.159-0.783]) and anterior vaginectomy, compared to no vaginectomy (HR, 2.595 [95% CI, 1.077-6.249]) were independently associated with vaginal cuff recurrence.

Conclusion: Anterior vaginectomy, despite our best attempts, is perhaps not sufficient to prevent vaginal cuff recurrence. Therefore, follow-up evaluation is essential, and further studies are necessary to address the optimal approach for initial management.

Patient Summary: Although vaginal cuff recurrence is an unusual site of recurrence, careful evaluation is needed before cystectomy and during follow-up to identify patients at risk.

Keywords: Urinary Bladder Neoplasms; Female; Neoplasm Metastasis; Recurrence

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Related Post

PCA3 rs544190G>A and prostate cancer risk in an eastern Chinese population

Vol. 44 (3): 500-505, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0146


ORIGINAL ARTICLE

Dalong Cao 1, 2, Chengyuan Gu 1, 2, Dingwei Ye 1, 2, Bo Dai 1, 2, Yao Zhu 1, 2
1 Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China; 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

ABSTRACT

Background: The association of prostate cancer antigen 3 (PCA3) polymorphism (SNP, rs544190G>A) with metastatic prostate cancer in European descent has been reported.

Our aim of the current study was to re-validate the effect of PCA3 polymorphism on prostate cancer risk in an Eastern Chinese population and then estimate possible genetic discrepancies among population.

Materials and Methods: Taqman assay was employed to determine genotype of SNP rs544190 in 1015 ethnic Han Chinese patients with prostate cancer and 1032 cancerfree controls. Simultaneously, odds ratios (OR) and 95% confidence intervals (95%CI) for risk relationship were calculated by logistic regression models.

Results: The statistically significant relationship between PCA3 rs544190G>A and higher prostate cancer risk was not found. Stratification analysis revealed that there was no remarkable association of rs544190 variant AG/AA genotype with prostate cancer risk in every subgroup, except for patients with Gleason score ≤7(3+4).

Conclusion: Although the results demonstrated that SNP rs544190 was not involved in prostate cancer risk in Eastern Chinese descent, unlike in European population, these might have clinical implications on prostate cancer heterogeneity around the World.

To validate these findings, well-designed studies with different ethnic populations are warranted.

Keywords: Prostatic Neoplasms; prostate cancer antigen 3, human [Supplementary Concept]; Polymorphism, Single Nucleotide

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Related Post

Nephrogenic adenoma of the bladder: a single institution experience assessing clinical factors

Vol. 44 (3): 506-511, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0155


ORIGINAL ARTICLE

Yooni Yi 1, Angela Wu 2, Anne P. Cameron 1
1 Deparment of Urology and 2 Deparment of Pathology, University of Michigan, Michigan, USA

ABSTRACT

Introduction: Nephrogenic adenoma (NA) was first described by Davis in 1949 as a “hamartoma” of the bladder. There are many proposed predisposing factors for NA in­cluding chronic inflammation, renal transplantation, and bladder cancer. We examined our experience with NA to determine predisposing factors and determine if there was any increased risk for development of subsequent malignancy.

Materials and Methods: All patients with a pathologic diagnosis of bladder NA from 2001-2013 were included. Patient history, clinical factors including possible predispos­ing factors for NA, and follow-up were reviewed.

Results: Among 60 patients, 68% were males with an average age of 61, an average BMI of 28.7, and 60% had a smoking history. In evaluating pro-inflammatory factors, 26.7% underwent either Bacillus Calmette-Guerin or mitomycin C, 30% had recurrent urinary tract infections, and 25% had a history of catheterization. Recurrence of NA after initial resection occurred only in 14.7% of patients who underwent follow-up cystoscopy. A history of concurrent bladder cancer was seen in 41.7% of patients, but there were no cases of de novo bladder cancer diagnosed after NA.

Conclusion: To the best of our knowledge, this is the largest series of patients with NA of the bladder. NA occurs in a heterogeneous population of patients, but most often with underlying inflammation. NA occurred concurrent with bladder cancer; however there were no cases of de novo bladder cancer after NA, reassuring that NA is likely a benign reactive condition.

 Keywords: Urinary Bladder Neoplasms; Adenoma; Urologic Diseases

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Related Post

Differences in the percutaneous nephrolithotomy practice patterns among Latin American urologists with and without endourology training

Vol. 44 (3): 512-523, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0599


ORIGINAL ARTICLE

Braulio O. Manzo 1, Edgar Lozada 1, Fabio C. Vicentini 2, Francisco Javier Sanchez 3, Gildardo Manzo 1
1 Hospital Regional de Alta Especialidade do Bajío, México; 2 Hospital das Clínicas da universidade de São Paulo, São Paulo, SP, Brasil; 3 Centro de Urologia do México (UROCEM), México

ABSTRACT

Purpose: Although the worldwide percutaneous nephrolithotomy (PCNL) practice patterns determined via a survey sent to members of the Endourological Society have been published, differences in PCNL practice patterns among Latin American urologists based on endourological or lithiasis training have not been published.

To determine the PCNL practice patterns among Latin American urologists with and without training in endourology.

Materials and Methods: The SurveyMonkey® web platform was used to develop a 27- item survey on PCNL for the treatment of renal stones, and the survey was sent via e-mail and other electronic media to 2000 urologists from 15 Latin American countries. Endourology-trained (group 1) and nontrained urologists (group 2) were analyzed. The group results were compared using the chi-squared and Fisher’s exact tests. SPSS version 20 for Windows was used for all analyses.

Results: A total of 331 urologists responded to the survey (rate of 16.55%): 221 (66.7%) in group 1 and 110 (33.2%) in group 2). In groups 1 and 2, 91.9% and 63.2% performed PCNL, respectively; 85.1% and 58.5% used preoperative tomography, respectively; 12.7% and 4.7% used preoperative nephrolitometry nomograms, respectively; 45.2% and 32.1% used endoscopic combined intrarenal surgery, respectively; 68.3% and 38.7% used mul­tiple percutaneous tract realization, respectively; and 19.9% and 5.7% used minimally invasive PCNL, respectively (all p=0.0005).

Conclusions: Statistically significant differences were observed in PCNL practice patterns of Latin American urologists with and without training in endourology. Specific training in endourology significantly influence the practice patterns of Latin American urologists.

Keywords: Nephrolithotomy, Percutaneous; Health Care Surveys; Kidney Calculi

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Related Post

Ureteral access sheaths: a comprehensive comparison of physical and mechanical properties

Vol. 44 (3): 524-535, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0575


ORIGINAL ARTICLE

Nishant Patel 1, Manoj Monga 1
1 Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, USA

ABSTRACT

Introduction: Ureteral access sheaths (UAS) facilitate flexible ureteroscopy in the treatment of urolithiasis. The physical properties of UAS vary by manufacturer and model.

We compared three new UAS: Glideway (GW, Terumo, 11/13Fr, 12/14Fr), Pathway (PW, Terumo 12/14F) and Navigator HD (NHD, Boston Scientific, 11/13Fr, 12/14Fr) in the domains of safety characteristics, positioning characteristics, lubricity and radioopacity.

Materials and Methods: In vitro testing of the three UAS included safety testing- tip perforation force, sheath edge deformation and dilator extraction forces. Positioning characteristics tested included tip bending, stiffness (resistance to coaxial buckling forces), kinking (resistance to perpendicular forces), and insertion forces. Lubricity was assessed by measured frictional forces of the outer sheath. Finally, radio-opacity was tested utilizing fluoroscopic imaging of the three 12F sheaths and inner dilators.

Results: The PW (0.245 lb) and GW (0.286 lb) required less force for tip perforation compared to the NHD (0.628 lb). The NHD sheath edge deformation was mild compared to more severe deformation for the PW and GW. The PW (1.008 lb) required greater force than the GW (0.136 lb) and NHD (0.043 lb) for inner dilator removal. The GW (3.69 lbs) and NHD (4.17 lb) had similar inner dilator tip stiffness when bent, while the PW had the weakest inner dilator tip, 1.91 lbs. The PW (0.271 lb) was most susceptible to buckling and kinking (1.626 lb). The most lubricious UAS was the NHD (0.055 lbs for 12F). The NHD (0.277 lbs) required the least insertional force through a biological model and possessed the greatest radio-opacity.

Conclusions: Comparison of different commercially available UAS in various sizes reveals that there are mechanical differences in sheaths that may play a role clinically.

The Terumo sheaths’ (GW and PW) were outperformed by the Boston Scientific NHD in simulating safety, ease of use and radio-opacity.

Keywords: Ureteroscopy; Ureter; instrumentation [Subheading]

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Related Post

Evaluation of urodynamic parameters after sling surgery in men with post-prostatectomy urinary incontinence

Vol. 44 (3): 536-542, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0243


ORIGINAL ARTICLE

Odair Gomes Paiva 1, João Paulo Cunha Lima 1, Carlos Alberto Bezerra 1
1 Disciplina de Urologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil

 

ABSTRACT

Objective: To evaluate urodynamic alterations after sub-urethral sling surgery (SSU) in patients with post-prostatectomy urinary incontinence (PPUI).

Materials and Methods: We evaluated data of 22 patients submitted to radical prosta­tectomy (RP) or transurethral resection of prostate (TURP) that presented post-surgical urinary incontinence and were treated with SSU implant in a pilot study previously performed in our institution.

Methods: Those patients with PPUI were evaluated by urodynamic exam (UD) before and after surgery, and the parameters were compared, including uroflow, cystometry and micturition study. Exclusion criteria included patients without pre-operatory uro­dynamic study, those with urethral stenosis, those not healed of prostate cancer, pa­tients without clinical conditions to be submitted to urodynamic study and those with severe neurological diseases or that refused to sign the consent form. Results were analyzed statistically by Fisher, Wilcoxon or Mann-Whitney tests.

Results: During free uroflow, none parameters showed any statistical significant differences. During cystometry, there were also no statistical differences and the same was observed at pressure versus flow study; the exception was at maximal flow detrusor pressure (PdetQmax), that was lower at post-operatory (p=0.028). In relation to the presence of urinary dysfunctions associated to PPUI, we observed a significant reduc­tion of detrusor overactivity (p=0.035) in relation to pre-operatory period.

Conclusion: SSU surgery significantly reduced detrusor overactivity and PdetQMax; however, there were no alterations of other evaluated urodynamic parameters.

Keywords: Suburethral Slings; Surgical Procedures, Operative; Urinary Incontinence

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Related Post

Functional outcomes and quality of life after transobturatory slings: hand – made vs. commercial slings

Vol. 44 (3): 543-549, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0524


ORIGINAL ARTICLE

Danilo Budib Lourenço 1, Fernando Korkes 1, José Eduardo Vetorazzo Filho 2, Silvia da Silva Carramão 3, Antônio Pedro Flores Auge 3, Luis Gustavo Morato de Toledo 2
1 Departamento de Urologia, Hospital Israelita Albert Einstein, São Paulo, SP, Brasil; 2 Departamento de Urologia; 3 Departamento de Ginecologia, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil

 

ABSTRACT

 

Surgical correction is the most efficient treatment for stress urinary incontinence (SUI), and transobturator sling (TO) has optimal results. The high cost of commercially available sling kits makes it difficult the access in most Brazilian public health services. Hand-made polypropylene slings, on the other hand, have been previously reported. The aim of the present study was to compare the effectiveness and safety of commercial vs. hand-made polypropylene mesh slings.

Data from 57 women who underwent consecutive TO sling surgery to treat SUI were pros­pectively collected between 2012 and 2014, and divided in two groups for further compa­rison. In Group-1, 31 women underwent surgery with commercial slings. In Group-2, 26 women underwent hand-made polypropylene slings. Women were compared according to epidemiological data, perioperative evaluation, quality of life, urodynamic study, cure and complication rates. Results were objectively (stress test with Valsalva maneuver, with at least 200mL vesical repletion) and subjectively evaluated by the Patient Global Impression of Improvement(PGI-I), Visual Analog Scale (VAS) and ICIQ-SF. Success was defined as PGI-I, VAS and negative stress test.

Group-1 (n=31) and Group-2 (n=26) had a mean age of 60 vs. 58years (p=0.386). All de­mographic data were similar. The mean VLPP was 75.6cmH2O vs. 76.6cmH2O (p=0.88). The mean follow-up was 24.3 vs. 21.5months (p=0.96). Success rates were 74.2% vs. 80.2% (p=0.556), with ICIQ-SF variation of 12.6 vs.15.5 (p=0.139) and PGI-I of 71% vs. 80% (p=0.225). There was only one major complication (urethrovaginal fistula in Group-1). In conclusion, handmade and commercial slings have similar effectiveness and safety. The manufacture technique has important key-points stated in the present manuscript.

Keywords: Urinary Incontinence, Stress; Pelvic Floor; Suburethral Slings

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Related Post

Sexual complications of penile frature in men who have sex with men

Vol. 44 (3): 550-554, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0520


ORIGINAL ARTICLE


Rodrigo Barros 1, Gabriel Lacerda 1, Alex Schul 1, Paulo Ornellas 1, Leandro Koifman 1, Luciano A. Favorito 2, 3
1 Hospital Municipal Souza Aguiar, Rio de Janeiro, RJ, Brasil; 2 Universidade Estadual do Rio de Janeiro (UERJ), RJ, Brasil; 3 Hospital Federal da Lagoa, Rio de Janeiro, RJ, Brasil

ABSTRACT  

Objectives: Evaluate the demographic data, etiology, operative findings and results of surgical treatment of penile fracture (PF) in men who have sex with men(MSM) with emphasis on sexual complications.

Materials and Methods: We studied 216 patients underwent surgical correction of PF at our hospital. Patients self-identified as MSM were followed for at least 6 months. Demographic data, presentation, operative findings, International Index of Erection Function – 5 (IIEF-5) and the Premature Ejaculation Diagnostic Tool.

Results: Of 216 PF cases, 4 (1.8%) were MSM. All cases resulted from sexual activity and all patients reported using the “doggy style” position during anal intercourse. Unilateral or bilateral injury of corpus cavernosum was found in 2 patients each. One (25%) patient had complete urethral injury associated with bilateral corpus caverno­sum lesion. During the follow-up period, all patients developed some type of sexual complication. One patient reported penile pain during intercourse. Another patient experienced low sexual desire and premature ejaculation. This patient was also dis­satisfied with the aesthetic result of the surgical scar and complained about decreased penis size after surgery. The third case developed delayed ejaculation. The fourth pa­tient experienced mild to moderate erectile dysfunction. This same patient presented with penile curvature. Finally, palpable fibrotic nodules in the operative area were observed in all cases.

Conclusions: Sexual activity in the “doggy style” position was the commonest cause of PF in MSM. Sexual dysfunction is always present in gay man after surgery for PF. However, additional studies with larger samples should be coinducted.

Keywords: Penis; Homosexuality; Coitus

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Related Post

Objective measurements of the penile angulation are significantly different than self-estimated magnitude among patients with penile curvature

Vol. 44 (3): 555-562, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0418


ORIGINAL ARTICLE

Giovanni Liguori 1, Andrea Salonia 2, Giulio Garaffa 3, Giovanni Chiriacò 1 , Nicola Pavan 1, Giorgio Cavallini 4, Carlo Trombetta 1
1 Department of Urology, University of Trieste, Trieste, Italy; 2 Department of Urology, Università Vita- Salute San Raffaele, Milan, Italy; 3 St Peter’s Andrology and the Institute of Urology, University College London Hospitals, London, UK; 4 Andrological Unit, Gynepro Medical Team; Bologna, Italy

 

ABSTRACT

Introduction: The study was aimed to assess the presence of actual differences between the objective and the perceived magnitude of a curvature between patients affected by Peyronie’s disease (PD) and congenital penile curvature (CPC).

Materials and Methods: Wee analysed a cohort of 88 consecutive patients seeking medi­cal help for either CPC or PD. All patients were invited to provide a self-made drawing of their penis in erection in order to obtain self-provided description of the deformity. An objective measurement of the deformity was also performed drawing two intersecting lines through the center of the distal and proximal straight section of the penile shaft.

Results: Our findings showed significant differences between patient self-estimation and the objective measurements of the penile angulation performed by trained experts, with only 32% of patients correctly assessing their own curvature. Overall, patients tended to overestimate (56%) their degree of curvature, but the results are different in patients with PD than those with CPC. In the 60 men (68%) who did not accurately assess their curvature, PD patients generally overestimated their curvature versus CPC patients (67% vs 16%). On the contrary CPC patients underestimated their curvature compared to PD (42% vs. 4%).

Conclusion: In order to improve patients’ satisfaction rates, the surgeon needs to take into consideration the patient’s perception of the deformity when planning the type of surgical correction.

Keywords: Penile Induration; Penis; Penile Erection

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Related Post

The history of varicocele: from antiquity to the modern ERA

Vol. 44 (3): 563-576, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0386


ORIGINAL ARTICLE

Antonio Marte 1
1 Unità di Chirurgia Pediatrica, Università della Campania – Luigi Vanvitelli, Napoli, Italia

 

ABSTRACT

Men have most likely been affected by varicocele since the assumption of the upright position. In De Medicina, written during the first century AD, Celsus credits the Greeks with the first description of a varicocele, and he recorded his own acute observation: “The veins are swollen and twisted over the testicle, which becomes smaller”. Celsus himself is credited with the distinction between varicocele (dilation of surface veins) and “cirsocele” (dilation of deep veins). There has been a long history of treatment attempts and failures, some of which are remarkably strange, that have sometimes cul­minated in tragedy, as in the case of French professor Jacques-Mathieu Delpech (1772- 1832). Although some questions regarding the etiopathology and treatment of varico­cele remain unanswered, a succession of more or less conservative attempts involving all medical cultures has been performed throughout history. The report by W.S. Tull­och in 1952 brought varicocele into the era of modern evidence-based medicine, and varicocele surgery finally progressed beyond the aim of merely relieving scrotal pain and swelling. From 1970 to 2000, varicocelectomies gained worldwide attention for the treatment of male infertility. Several innovative procedures to correct varicoceles began to appear in the world’s literature as interventional radiology, microsurgery, laparoscopy, and robotics, while comprehensive review articles were also published on the subject of varicocelectomies. Microsurgery is nowadays used worldwide and it can be considered to be the gold standard for correcting infertility linked to varicocele.

Keywords:  Varicocele; history of medicine

[Full Text]


Related Post

99mTc-DTPA Diuretic Renography with 3 hours late output fraction in the evaluation of hydronephrosis in children

Vol. 44 (3): 577-584, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0131


ORIGINAL ARTICLE

Carlos J. R. Simal 1, 2
1 Departamento de Anatomia e Imagem, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Brasil; 2 Divisão de Medicina Nuclear, Hospital Felicio Rocho, Belo Horizonte, Minas Gerais, Brasil

ABSTRACT

Objective: Dynamic renal scintigraphy complemented by late gravity assisted postvoid images to 60 minutes is a frequently used diagnostic test in the evaluation of hydrone­phrosis. The objective of this study is to evaluate the effectiveness in acquiring images at 180 minutes to calculate the late output fraction (LOF) of 99mTc-DTPA in the diagno­sis of ureteropelvic junction obstruction (UPJO).

Materials and Methods: A retrospective study of 177 patients (196 renal units) of sus­pected cases of clinical UPJO was conducted. The patients were submitted to at least two dynamic renal scintigraphies of 99mTc-DTPA, with the addition of furosemide (F0), with a mean age of 4.3+3.8 years for the first study, and a follow-up of 2.7+2.5 years.

Results: For diagnosis based on renal curves, a 100% sensitivity, 82.2% specificity, positive predictive value (PPV) of 10.4% and negative predictive value (NPV) of 100% were estimated. For diagnosis based on LOF, a 100% sensitivity, 96.3% specificity, PPV of 35.7% and NPV of 100% were estimated.

Conclusion: A LOF <10% is indicative of UPJO, and a LOF >15% is indicative of no UPJO. The data demonstrate that LOF presents equivalent sensitivity and NPV, and higher specificity and PPV in comparison to diagnosis based on renal curves, and is useful in the evaluation and follow-up of suspected cases of UPJO.

Keywords: Hydronephrosis; Ureteral Obstruction; Cakut [Supplementary Concept]; Technetium Tc 99m Pentetate

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Related Post

Durasphere® EXP: a non-biodegradable agent for treatment of primary Vesico-Ureteral reflux in children

Vol. 44 (3): 585-590, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0514


ORIGINAL ARTICLE

Unsal Ozkuvanci 1, Muhammet Irfan Donmez 2, Faruk Ozgor 1, Akif Erbin 1, Özge Pasin 3, Ahmet Yaser Muslumanoglu 1
1 Department of Urology Haseki Training and Research Hospital, Fatih, Istanbul, Turkey; 2 Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Fatih, Istanbul, Turkey; 3 Department of Biostatistics, Istanbul Faculty of Medicine, Istanbul University, Fatih, Istanbul, Turkey

ABSTRACT

 

Introduction: Durasphere® EXP (DEXP) is a compound of biocompatible and non­-biodegradable particles of zirconium oxide covered with pyrolytic carbon. The aim of this study is to evaluate the durability of off-label use of DEXP in the treatment of primary vesicoureteral reflux in children.

Materials and Methods: Patients who underwent subureteric injection of DEXP for the correction of primary VUR were retrospectively reviewed . Patients aged >18 years as well as those who had grade-I or -V VUR, anatomic abnormalities (duplicated system, hutch diverticulum), neurogenic bladder or treatment refractory voiding dysfunction were excluded. Radiologic success was defined as the resolution of VUR at the 3rd month control. Success was radiographically evaluated at the end of the first year.

Results: Thirty-eight patients (9 boys, 29 girls; mean age, 6.3±2.7 years) formed the study cohort. Forty-six renal units received DEXP (grade II: 22; grade III: 18; grade IV: 6). Mean volume per ureteric orifice to obtain the mound was 0.70±0.16mL. First con­trol VCUG was done after 3 months in all patients. After the first VCUG, 6 patients had VUR recurrence. Short-term radiologic success of DEXP was 84.2%. Rate of radiologic success at the end of the first year was 69.4% (25/32). Lower age (p:0.006) and lower amount of injected material (p:0.05) were associated with higher success rates at the end of 1 year.

Conclusion: This is the first study to assess the outcomes of DEXP for treatment of primary VUR in children. After 1 year of follow-up, DEXP had a 69.4% success rate.

Keywords: Durasphere [Supplementary Concept]; Vesico-Ureteral Reflux; Child

[Full Text]


 

Related Post

Preoperative care of Polypoid exposed mucosal template in bladder exstrophy: the role of high-barrier plastic wraps in reducing inflammation and polyp size

Vol. 44 (3): 591-599, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0196


ORIGINAL ARTICLE

Nastaran Sabetkish 1, Shabnam Sabetkish 1, Abdol-Mohammad Kajbafzadeh 1
1 Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran (IRI)

ABSTRACT

Objective: To assess the role of high-barrier plastic wrap in reducing the number and size of polyps, as well as decreasing the inflammation and allergic reactions in exstrophy cases, and to compare the results with the application of low-barrier wrap.

Materials and Methods: Eight patients with bladder exstrophy-epispadias complex (BEEC) that had used a low density polyethylene (LDPE) wrap for coverage of the exposed polypoid bladder in preoperative care management were referred. The main complaint of their parents was increase in size and number of polyps. After a period of 2 months using the same wrap and observing the increasing pattern in size of polyps, these patients were recommended to use a high-barrier wrap which is made of polyvinylidene chloride (PVdC), until closure. Patients were monitored for the number and size of polyps before and after the change of barriers. The incidence of para-exstrophy skin infection/inflammation and skin allergy were assessed. Biopsies were taken from the polyps to identify histopathological characteristics of the exposed polyps.

Results: The high barrier wrap was applied for a mean ± SD duration of 12±2.1 months. Polyps’ size and number decreased after 12 months. No allergic reaction was detected in patients after the usage of PVdC; three patients suffered from low-grade skin allergy when LDPE was applied. Also, pre-malignant changes were observed in none of the patients in histopathological examination after the application of PVdC.

Conclusion: Polyps’ size and number and skin allergy may significantly decrease with the use of a high-barrier wrap. Certain PVdC wraps with more integrity and less evaporative permeability may be more “exstrophy-friendly”.

 

Keywords: Bladder Exstrophy; Cosmetics; Infection; Polyps

[Full Text]


 

Related Post

Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study

Vol. 44 (3): 600-607, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0668


ORIGINAL ARTICLE

Mehmet Demir 1, Yigit Akin 1, 2, Kubra Asena Kapakin Terim 3, Mehmet Gulum 4, Evren Buyukfirat 5, Halil Ciftci 1, Ercan Yeni 1
1 Department of Urology, Harran University School of Medicine, Sanliurfa, Turkey; 2 Department of Urology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey; 3 Department of Pathology, Ataturk University School of Veterinary Medicine, Erzurum, Turkey; 4 Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey; 5 Department of Anaesthesiology, Harran University School of Medicine, Sanliurfa, Turkey

 

ABSTRACT

Objectives: Apoptosis effect of oral alpha-blockers is known in the prostate. Apoptosis index of silodosin has not been proved, yet. Aims are to present apoptosis index of silodosin in prostate and to compare this with other currently used alpha-blocker’s apoptosis indexes together with their clinical effects.

Materials and Methods: Benign prostatic hyperplasia (BPH) patients were enrolled among those admitted to urology outpatient clinic between June 2014 and June 2015. Study groups were created according to randomly prescribed oral alpha-blocker drugs as silodosin 8mg (Group 1; n=24), tamsulosin 0.4mg (Group 2; n=30), alfuzosin 10mg (Group 3; n=25), doxazosin 8mg (Group 4; n=22), terazosin 5mg (Group 5; n=15). Pa­tients who refused to use any alpha-blocker drug were included into Group 6 as control group (n=16). We investigated apoptosis indexes of the drugs in prostatic tissues that were taken from patient’s surgery (transurethral resection of prostate) and/or prostate biopsies. Immunochemical dyeing, light microscope, and Image Processing and Analy­sis in Java were used for evaluations. Statistical significant p was p<0.05.

Results: There were 132 patients with mean follow-up of 4.2±2.1 months. Pathologist researched randomly selected 10 areas in each microscope set. Group 1 showed statisti­cal significant difference apoptosis index in immunochemical TUNEL dyeing and im­age software (p<0.001). Moreover, we determined superior significant development in parameters as uroflowmetry, quality of life scores, and international prostate symptom score in Group 1.

Conclusions: Silodosin has higher apoptosis effect than other alpha-blockers in pros­tate. Thus, clinic improvement with silodosin was proved by histologic studies. Besides, static factor of BPH may be overcome with creating apoptosis.

Keywords: Prostate; Prostatic Hyperplasia; 5-alpha Reductase Inhibitors

[Full Text]


Related Post

The role of fetal-maternal microchimerism as a natural-born healer in integrity improvement of maternal damaged kidney

Vol. 44 (3): 608-616, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0324


ORIGINAL ARTICLE

Abdol-Mohammad Kajbafzadeh 1, Shabnam Sabetkish 1, Nastaran Sabetkish 1
1 Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran

ABSTRACT

Purpose: To identify the fetal stem cell (FSC) response to maternal renal injury with emphasis on renal integrity improvement and Y chromosome detection in damaged maternal kidney.

Materials and Methods: Eight non-green fluorescent protein (GFP) transgenic Sprague- Dawley rats were mated with GFP-positive transgenic male rats. Renal damage was induced on the right kidney at gestational day 11. The same procedure was performed in eight non-pregnant rats as control group. Three months after delivery, right ne­phrectomy was performed in order to evaluate the injured kidney. The fresh perfused kidneys were stained with anti-GFP antibody. Polymerase chain reaction (PCR) assay was also performed for the Y chromosome detection. Cell culture was performed to detect the GFP-positive cells. Technetium-99m-DMSA renal scan and single-photon emission computed tomography (SPECT) were performed after renal damage induction and 3 months later to evaluate the improvement of renal integrity.

Results: The presence of FSCs was confirmed by immune histochemical staining as well as immunofluorescent imaging of the damaged part. Gradient PCR of female rat purified DNA demonstrated the presence of Y-chromosome in the damaged maternal kidney. Moreover, the culture of kidney cells showed GPF- positive cells by immuno­fluorescence microscopy. The acute renal scar was repaired and the integrity of dam­aged kidney reached to near normal levels in experimental group as shown in DMSA scan. However, no significant improvement was observed in control group.

Conclusion: FSC seems to be the main mechanism in repairing of the maternal renal injury during pregnancy as indicated by Y chromosome and GFP-positive cells in the sub-cultured medium.

Keywords:  Fetal Stem Cells; Y Chromosome; Technetium Tc 99m Dimercaptosuccinic Acid; Green Fluorescent Proteins

[Full Text]


Related Post

The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury

Vol. 44 (3): 617-622, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0600


ORIGINAL ARTICLE

Mehmet Ali Karagoz 1,Omer Gokhan Doluoglu 1, Hatice Ünverdi 2, Berkan Resorlu 3, Mehmet Melih Sunay 4, Arif Demirbas 4, Tolga Karakan 1, 4, Arif Aydin 5
1 Department of Urology, Ankara Training and Research Hospital, Ankara, Turkey; 2 Deparment of Pathology Ankara Training Research Hospital, Ankara, Turkey; 3 Department of Urology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey; 4 Saglik Bakanligi Ankara Egitim ve Arastirma Hastanesi Ankara, Ankara, Turkey; 5 Department of Urology, Faculty of Medicine, Necmettin Erbakan University Meram, Konya, Turkey

ABSTRACT  

Objective: To investigate the effect of papaverine and alprostadil on testicular torsion-detorsion injury in rats.

Materials and Methods: A total of 40 male Wistar-Albino rats were used in this study. Four hours of right testicular torsion was applied to each group, excluding sham oper­ated group. The torsion-detorsion (T/D), T/D + papaverine and T/D + alprostadil groups received saline, papaverine and alprostadil at the same time as surgical detorsion, respectively. At 14 days after the surgical detorsion, ischaemic changes and the degree of damage were evaluated with Cosentino scoring and the Johnson tubular biopsy score (JTBS).

Results: JTBS was determined as 8.8±2.7 in the Sham group, 5.08±1.9 in the T/ D+papaverine group, 5.29±2.3 in the T/D +alprostadil group and 2.86±1.9 in the TD group. The JTBS was determined to be statistically significantly high in both the T/D + papaverine group and the T/D + alprostadil group compared to the T/D group (p=0.01, p=0.009). In the T/D + papaverine group, 3 (43 %) testes were classified as Cosentino 2, 3 (43%) as Cosentino 3 and 1 (14 %) as Cosentino 4. In the T/D +alprostadil group, 5 (50 %) testes were classified as Cosentino 2, 3 (30 %) as Cosentino 3 and 2 (20%) as Cosentino 4.

Conclusion: The present study indicated that spermatic cord administration of alprosta­dil and papaverine showed a protective effect against ischemia/reperfusion injury after right-side testes torsion and histological changes were decreased after testicular isch­emia reperfusion injury.

Keywords: Papaverine; Alprostadil; Spermatic Cord Torsion

[Full Text]


Related Post

Editorial Comment: The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury

Vol. 44 (3): 623-623, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0600.1


EDITORIAL

Fernando Lorenzini 1
1 Centro de Reprodução Humana Curitiba, PR, Brasil

ABSTRACT

Not Available

[Full Text]


 

Related Post

Ureteroileal bypass: a new technic to treat ureteroenteric strictures in urinary diversion

Vol. 44 (3): 624-628, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0014


SURGICAL TECHNIQUE

Guilherme P. Padovani 1, Marcos F. Mello 1, Rafael F. Coelho 1, Leonardo L. Borges 1, Adriano Nesrallah 1, Miguel Srougi 1, William C. Nahas 1 Guilherme P. Padovani 1, Marcos F. Mello 1, Rafael F. Coelho 1, Leonardo L. Borges 1, Adriano Nesrallah 1, Miguel Srougi 1, William C. Nahas 1
1 Divisão de Urologia, Faculdade de Medicina da Universidade de São Paulo, SP, Brasil

 

ABSTRACT

Objective: To present our technique of ureteroileal bypass to treat uretero-enteric strictures in urinary diversion.

Materials and Methods: One hundred and forty-one medical records were reviewed from patients submitted to radical cystectomy to treat muscle-invasive bladder cancer between 2013 and 2015. Twelve (8.5%) patients developed uretero-enteric anastomotic stricture during follow-up. Five patients were treated with endoscopic dilatation and double J placement. Four were treated surgically with standard terminal-lateral implantation.

Three patients with uretero-enteric anastomotic stricture were treated at our institution by “ureteroileal bypass”, one of them was treated with robotic surgery.

Results: All patients had the diagnosis of uretero-enteric anastomotic stricture via computerized tomography and DTPA renal scan. Time between cystectomy and diagnosis of uretero-enteric anastomotic stricture varied from five months to three years. Mean operative time was 120±17.9 minutes (98 to 142 min) and hospital stay was 3.3±0.62 days (3 to 4 days). Mean follow-up was 24±39.5 months (6 to 72 months). During follow-up, all patients were asymptomatic and presented improvement in ureterohydronephrosis. Serum creatinine of all patients had been stable.

Conclusions: Latero-lateral ureter re-implantation is feasible by open or even robotic surgery with positive results, reasonable operation time, and without complications.

Keywords: Urinary Diversion, Cystectomy, Urinary Bladder

[Full Text]


Related Post

Laparoscopic approach to pheochromocytoma in pregnancy: case report

Vol. 44 (3): 629-633, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0540


CHALLENGING CLINICAL CASES

Felipe de Almeida e Paula 1,2,3, Ravisio Israel dos Santos Junior 1,2,3, Odivaldo Antonio Ferruzzi 2, Rafael Osti de Melo 3, Mariana Takaku 1,2
1 Hospital Regional do Câncer de Presidente Prudente, Presidente Prudente, SP, Brasil; 2 Santa Casa de Misericórdia de Presidente Prudente, Presidente Prudente, SP, Brasil; 3 Faculdade de Medicina de Presidente Prudente, Universidade do Oeste Paulista, Presidente Prudente, SP, Brasil

ABSTRACT

A 32-year-old 22-week pregnant hypertensive woman with sporadic episodes of headaches, sweating, and facial flushing was diagnosed with pheochromocyto­ma through biochemical and imaging tests. Perioperative management included a multidisciplinary approach, symptom stabilization with ɑ blockade followed by ß blockade, and tumor resection by laparoscopic adrenalectomy at 24 weeks gesta­tion. The diagnosis was confirmed by histopathological examination and immuno­histochemistry tests. The decision for surgical removal of the tumor was based on maternal symptoms, tumor size, gestational age, the possibility of doing a laparos­copy, and the expertise of the surgical team.

Keywords: Pheochromocytoma; Pregnancy; Laparoscopy

[Full Text]


Related Post

Salvage surgical procedure for artificial sphincter extrusion

Vol. 44 (3): 634-638, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0462


CHALLENGING CLINICAL CASES

Flavio Trigo Rocha 1, Jean Felipe Prodocimo Lesting 1
1 Centro de Incontinência Urinaria, Hospital Sírio Libanês, SP, Brasil

ABSTRACT

Case Hypothesis: Surgical removal is the standard treatment for artificial sphincter extrusion. However in some specific situations is possible to maintain the prosthesis with good results.

Case report: We report a 60 years old patient presenting sphincter pump extrusion one month after artificial urinary sphincter (AUS) AMS 800™ placement for treating post-radical prostatectomy urinary incontinence (PRPUI). He also had a penile prosthesis implant one year before that was replaced in the same surgery the sphincter was implanted. As patient refused sphincter removal and there were no signals of active infection he was treated by extensive surgical washing with antibiotics and antiseptics.

Pump was repositioned in the opposite side of the scrotum. Patient had good evolution with sphincter activation 50 days later. After 10 months of follow up, patient is socially continent and having regular sexual intercourse. Savage surgery may be an option in select cases of artificial sphincter extrusion.

Promising future implications: Like in some patients with penile prosthesis some patients with artificial sphincter extrusion can be treated without removing the device.

This may be a line of research about conservative treatment of artificial sphincter complications.

Keywords: Urinary Incontinence; Surgical Procedures, Operative; Urinary Sphincter, Artificial

[Full Text]


 

Related Post

Extrarenal Angiomyolipoma: differential diagnosis of retroperitoneal masses

Vol. 44 (3): 639-641, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2016.0670


RADIOLOGY PAGE

Marcelo Wroclawski 1, Willy Baccaglini 2, Cristiano Linck Pazeto 2, Cristina Carbajo 2, Chaline Matushita 2, Arie Carneiro 2, Alexandre Pompeo 2, Sidney Glina 2, Antonio Carlos Lima Pompeo 2, Lívia Barreira Cavalcante 3
1 Hospital Israelita Albert Einstein, São Paulo, SP, Brasil; 2 Departamento de Urologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil; 3 Centro de Imuno-Histoquímica, Citopatologia e Anatomia Patológica (CICAP) São Paulo, SP, Brasil
No abstract available

[Full Text]


Related Post

Extensive renal sinus lipomatosis in xanthogranulomatous pyelonephritis simulating liposarcoma

Vol. 44 (3): 642-644, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0509


RADIOLOGY PAGE

Sabrina de Mello Ando 1, Raquel Andrade Moreno 1, Públio Cesar Cavalcante Viana 1, Fernando Ide Yamauchi 1
1 Departamento de Radiologia, Hospital das Clínicas da Universidade de São Paulo HC-FMUSP, São Paulo, Brasil

ABSTRACT

Renal replacement lipomatosis is a condition characterized by varying degrees of renal parenchymal atrophy and perirenal fibrofatty proliferation secondary to chronic inflammation such as xanthogranulomatous pyelonephritis. In severe cases, imaging findings can be misdiagnosed as retroperitoneal liposarcoma.

[Full Text]


 

Related Post

Saphenous-sparing laparoscopic inguinal lymphadenectomy

Vol. 44 (3): 645-646, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0120


VIDEO SECTION

Gaetano Chiapparrone 1, Sebastiano Rapisarda 2, Bernardino de Concilio 2, Guglielmo Zeccolini 2, Michele Antoniutti 2, Antonio Celia 2
1 Department of Urology, Ospedale do Cattinara, Trieste – Italy; 2 San Bassiano Hospital – Urology, Bassano del Grappa, Italy

ABSTRACT

Introduction: Inguinal lymphadenectomy is an integral part in the management of penile cancer. Video endoscopic in­guinal lymphadenectomy (VEIL) is emerging as a minimally invasive treatment to reduce postoperative complications.

Materials and Methods: 62 years old man underwent glansectomy for a squamous cell carcinoma (pT1b). At the physical examination one left inguinal lymph node was detectable (cN1). The chest-abdomen-pelvis CT was negative for me­tastasis. A 10-mm optical trocar and two 5mm operating trocar were placed. The optical trocar was placed in the apex of Scarpa’s triangle after a skin incision and after the creation of a subcutaneous space by blunt finger dissection. The pCO2 was 8-10mmHg. The surgical technique involved the removal of superficial lymph nodes according to the scheme described by Deseler and of the deep lymph nodes. Sparing main venous structures and closing lymphatic vessels is im­portant to reduce post operative complications. At the end of the procedure, a suction drain was placed per side.

Results: Operative time was 90 minutes per side. Drains were removed on the seventh postoperative day. Hospital stay was 8 days and no postoperative complications occurred. The total number of nodes removed was 16 (8 per side) with 2 superficial positive nodes on the left side.

Conclusion: ILND is burned by a high complication rate. VEIL provides a less invasive approach and a saphenous-sparing technique ensures a lower complication rate, reducing lymphorrhea, skin necrosis and wound complications (1-3). In experienced laparoscopic hands, VEIL is a safe and effective treatment.

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Surgical repair in case of covered exstrophy of bladder with complete duplication of lower genitourinary tract and visceral sequestration

Vol. 44 (3): 647-648, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2016.0634


VIDEO SECTION

Sachin Sarode 1, Sunil Mhaske 2, Vinayak G. Wagaskar 1, Bhushan Patil 1, Sujata K. Patwardhan 1, Ganesh Gopalakrishnan 3
1 Department of Urology, Seth GSMC and King’s Edward Memorial Hospital, Mumbai, India; 2 Department of Urology, Dr. D. Y. Patil Medical College Pimpri, Pune, India; 3 Department of Urology, Vednayagam Hospital, Coimbatore, India

 

No abstract available

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Vol. 44 (3): 649-650, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0409


VIDEO SECTION

Kaan Gokcen 1, Gokce Dundar 2, Gokhan Gokce 1, Emin Yener Gultekin 1
1 Cumhuriyet University Faculty of Medine, Department of Urology, Sivas, Turkey; 2 Cizre State Hospital, Department of Urology, Cizre, Turkey

 

No abstract available

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Retroperitoneoscopic nephrectomy for huge autosomal-dominant polycystic kidney disease using morcellator

Vol. 44 (3): 651-652, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0258


VIDEO SECTION

Dong Sup Lee 1, Hee Youn Kim 1, Seung-Ju Lee 1
1 Department of Urology, The Catholic University of Korea, St. Vincent’s Hospital, South Korea

 

No abstract available

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Re: Gaseous bladder tamponade secondary to emphysematous cystitis

Vol. 44 (3): 653-654, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2017.0701


LETTER TO THE EDITOR

Yu-Chen Chen 1,2, Hao-Wei Chen 1,2, Yung-Shun Juan 3, Wen-Jeng Wu 3, Chia-Chun Tsai 3
1 Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 2 Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Taiwan; 3 Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan

 ABSTRACT

No abstract available

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Re: Dipyridamole reduces penile apoptosis in a rat model of post-prostatectomy erectile dysfunction

Vol. 44 (3): 655-656, May – June, 2018

doi: 10.1590/S1677-5538.IBJU.2018.0016


LETTER TO THE EDITOR

Shanzun Wei 1,2, Ming Ma 1,2, Changjing Wu 1, Botao Yu 1,2, Jiuhong Yuan 1,2
1 Andrology Laboratory and 2 Department of Urology, Westchina Hospital, SiChuan University, China

ABSTRACT

No abstract available

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