Posts made in November, 2016

Effect of platelet-rich plasma on polypropylene meshes implanted in the rabbit vagina: histological analysis

Vol. 42 (x): 2016 November 6.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2016.0177


Natália Gomes Parizzi 1, Oscar Ávila Rubini 2, Silvio Henrique Maia de Almeida 1, Lais Caetano Ireno 1, Roger Mitio Tashiro 1, Victor Hugo Tolotto de Carvalho 1

1 Departamento de Cirurgia, Universidade Estadual de Londrina, Londrina, PR, Brasil; 2 Departamento de Cirurgia, Universidade do Oeste Paulista, Presidente Prudente, SP, Brasil



Purpose: The polypropylene mesh (PPM) is used in many surgical interventions because of its good incorporation and accessibility. However, potential mesh-related complications are common. Platelet-rich plasma (PRP) improves the healing of wounds and is inexpensive. Thus, the purpose of this study was to analyze the effect of the PRP-gel coating of a PPM on inflammation, production of collagen, and smooth muscle in the rabbit vagina.

Materials and Methods: The intervention consisted of a 1.5cm incision and divulsion of the vaginal mucosa for the implantation of a PRP-coated PPM. The PRP-coated mesh was implanted in 15 rabbits, and in the second group, the same implant was used without the PRP coating. In the sham group, the intervention consisted of the incision, divulsion, and suture. The rabbits were euthanized at 7, 30 and 90 days, and full-thickness sagittal sections of the posterior vaginal wall and rectum were scored.

The inflammatory infiltrate was evaluated using hematoxylin and eosin staining. The Sirius Red stain was used to examine deposition of collagen I and III, and Masson’s trichrome staining was used to visualize the...

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Ultrasound detection of prostatic calculi as a parameter to predict the appearance of hematospermia after a prostate biopsy

Vol. 42 (x): 2016 November 6.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2016.0005


Lucio Dell’Atti 1

1 Department of Urology, University Hospital “St.Anna”, Ferrara, Italy


Purpose: We evaluated the correlation between prostate calculi and hematospermia in patients undergoing prostate biopsy, and its impact on sexual activity of patients.

Materials and Methods: A single-center prospective randomized study of 212 patients referred for transrectal ultrasound-guided prostate biopsy (TRUSBx) was performed. All patients were divided into two groups: Group A (GA), 106 patients with moderate/ marked presence of prostatic calculi visualized by TRUS; Group B (GB), 106 patients with absence/scarce of prostatic calcifications. Patients were handed questionnaires to obtain a validated data on the duration and impact of hematospermia on sexual activ­ity. The anxiety scores were recorded using a visual analogue scale.

Results: No significant difference was noted between the two groups when comparing age, preoperative PSA level, prostate volume, and biopsy number, except for digital rectal examination (DRE) findings. Post-biopsy results of patients included in GA re­vealed that the complication of hematospermia was present in 65.1%, while in GB was present in 39.7% (p<0.001).

On multivariate analysis for identifying significant preoperative predictors of hemato­spermia, which included variables of age, PSA, prostate volume, and prostate cancer were not shown to be significant predictors of hematospermia, except DRE and pros­tate calculi (p<0.001).

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Novel penile circumcision suturing devices versus the shang ring for adult male circumcision: a prospective study

Vol. 42 (x): 2016 November 6.[Ahead of print]

doi: 10.1590/S1677-5538.IBJU.2016.0204


Hu Han 1, Da-wei Xie 1, Xiao-guang Zhou 1, Xiao-dong Zhang 1

1 Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China


Introduction: To evaluate the safety and efficacy of a novel penile circumcision sutur­ing devices PCSD and Shang ring (SR) for circumcision in an adult population.

Materials and Methods: A total of 124 outpatients were randomly assigned to receive PCSD (n=62) or SR (n=62). Patient characteristics, operative time, blood loss, return to normal activities time (RNAT), visual analogue scale (VAS), scar width, wound healing time, cosmetic result, and complications were recorded.

Results: There were no significant differences in blood loss, RNAT, or complications between the two groups. There were no significant differences in the VAS scores at theduring operation, and 6 or 24 hours after surgery (P>0.05). The wound scar width was wider in the SR group than in the PCSD group (P<0.01). Patients in the SR group had significantly longer wound healing time compared with those in the PCSD group (P<0.01). Patients who underwent PCSD wereere significantly more satisfied with the cosmetic results (P<0.01).

Conclusions: SR and PCSD are safe and effective minimally invasive techniques for adult male circumcision. Compared with SRs, PCSDs have the advantages of faster postoperative incision healing and a good effect on wound cosmetics.

Keywords:  Circumcision, Male; Penis; Surgical Procedures, Operative

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Penile Cancer: The Importance to predict lymph node metastasis

Vol. 42 (6): 1056-1057, November – December, 2016

doi: 10.1590/S1677-5538.IBJU.2016.06.01

EDITORIAL in this Issue

Luciano A. Favorito

Professor Associado da Unidade de Pesquisa Urogenital da Universidade do Estado de Rio de Janeiro
Urologista do Hospital da Lagoa Federal, Rio de Janeiro
Editor Associado da International Braz J Urol

No Abstract Available

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Data vs Dogma in Peyronie’s Disease

Vol. 42 (6): 1058-1061, November – December, 2016

doi: 10.1590/S1677-5538.IBJU.2016.06.02


Ryan P. Terlecki 1, Alison M. Rasper 1

1 Wake Forest Baptist Health, NY, USA

Curvature of the erect penis from elements of internal fibrosis has been recognized for centuries (first described in 1743), yet our understanding still seems limited. Guidelines exist in both the United States and Europe, with most based on low level evidence and opinion (1, 2). Men afflicted by this situation are typically lumped together and labeled with the singular descriptor of Peyronie’s disease. The level of evidence for the pathophysiology and natural history of this affliction is poor, as is the awareness of data surrounding treatment modalities. This is evidenced by the fact that one of the most commonly provided interventions is Vitamin E, which has not been shown to provide benefit and is not recommended by existing guidelines. In medical practice, it is dangerous to equate shared assumptions with fact, as this may limit pursuit of additional knowledge. Additionally, in the absence of evidence, logic should prevail.

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